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Table 2 Expression of nuclear and cytoplasmic Ep-ICD and membranous EpEx in normal tissues and breast cancer histotypes

From: Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients

Tissue type

Number of tissues N

Nuclear Ep-ICD positivity n (%)

Cytoplasmic Ep-ICD positivity n (%)

Membranous EpEx positivity n (%)

Loss of membranous EpEx n (%)

Normal

45

11 (24% )

39 (87%)

19 (42%)

26 (58%)

Breast cancer

266

121 (46%)

215 (81%)

185 (70%)

81 (30%)

Histotypes *

     

DCIS

61 (22.9%)

30 (49%)

48 (79%)

47 (77%)

14 (23%)

IDC

180 (67.6%)

75 (42%)

145 (81%)

128 (71%)

52 (29%)

ILC

15

10

12

3

12

IMC

9

5

9

6

3

  1. For nuclear Ep-ICD a cut off of ≥ 2 was used to determine positivity. For cytoplasmic Ep-ICD the cut off was ≥ 4. For membranous EpEx a cut off of ≥ 3 was considered positive.
  2. *1 LCIS was also included in the study (data not shown in table).