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Table 2 Expression of nuclear and cytoplasmic Ep-ICD and membranous EpEx in normal tissues and breast cancer histotypes

From: Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients

Tissue type Number of tissues N Nuclear Ep-ICD positivity n (%) Cytoplasmic Ep-ICD positivity n (%) Membranous EpEx positivity n (%) Loss of membranous EpEx n (%)
Normal 45 11 (24% ) 39 (87%) 19 (42%) 26 (58%)
Breast cancer 266 121 (46%) 215 (81%) 185 (70%) 81 (30%)
Histotypes *      
DCIS 61 (22.9%) 30 (49%) 48 (79%) 47 (77%) 14 (23%)
IDC 180 (67.6%) 75 (42%) 145 (81%) 128 (71%) 52 (29%)
ILC 15 10 12 3 12
IMC 9 5 9 6 3
  1. For nuclear Ep-ICD a cut off of ≥ 2 was used to determine positivity. For cytoplasmic Ep-ICD the cut off was ≥ 4. For membranous EpEx a cut off of ≥ 3 was considered positive.
  2. *1 LCIS was also included in the study (data not shown in table).