Table 3 Associations between patient- and therapy-related characteristics and acute G2+ dermatitis
| Â | Â | All (n = 377) | G0-1 (n = 157) | G2+ (n = 220) | p-value | pBH-value |
|---|---|---|---|---|---|---|
Bra cup size | Â | Â | Â | Â | Â | Â |
| Â | A + B + C | 269 (71.4) | 130 (48.3) | 139 (51.7) | Â | Â |
|  | ≥D | 103 (27.3) | 26 (25.2) | 77 (74.8) | <0.001 | 0.001 |
BMI | Â | Â | Â | Â | Â | Â |
| Â | Median | 26 | 24 | 26 | Â | Â |
Range | 16-50 | 16-37 | 16-50 | <0.001 | 0.001 | |
Smoking during RT | Â | Â | Â | Â | Â | Â |
| Â | No | 323 (85.7) | 141 (43.7) | 182 (56.3) | Â | Â |
| Â | Yes | 51 (13.5) | 14 (27.5) | 37 (72.5) | 0.029 | 0.156 |
Fractionation | Â | Â | Â | Â | Â | Â |
| Â | Normo | 45 (11.9) | 6 (13.3) | 39 (86.7) | Â | Â |
| Â | Hypo | 332 (88.1) | 151 (45.5) | 181 (54.5) | <0.001 | <0.001 |
Treatment position | Â | Â | Â | Â | Â | Â |
| Â | Supine | 290 (76.9) | 108 (37.2) | 182 (62.8) | Â | Â |
| Â | Prone | 87 (23.1) | 49 (56.3) | 38 (43.7) | 0.002 | 0.019 |
Nodal irradiation | Â | Â | Â | Â | Â | Â |
| Â | No | 315 (83.6) | 141 (44.8) | 174 (55.2) | Â | Â |
| Â | Yes | 62 (16.4) | 16 (25.8) | 46 (74.2) | 0.006 | 0.037 |
Hormonal therapy | Â | Â | Â | Â | Â | Â |
| Â | No | 71 (18.8) | 39 (54.9) | 32 (45.1) | Â | Â |
| Â | Concomitant | 243 (64.5) | 94 (38.7) | 149 (61.3) | Â | Â |
| Â | Sequential (after IMRT) | 63 (16.7) | 24 (38.1) | 39 (61.9) | 0.041 | 0.207 |
| Â | Hormones (concomitant) | Â | Â | Â | Â | Â |
| Â | Tamoxifen | 155 | 62 (40.0) | 93 (60.0) | Â | Â |
| Â | Aromatase inhibitor | 85 | 32 (37.6) | 53 (62.4) | Â | Â |
Chemotherapy | Â | Â | Â | Â | Â | Â |
| Â | No | 243 (64.5) | 92 (37.9) | 151 (62.1) | Â | Â |
| Â | Yes | 134 (35.5) | 65 (48.5) | 69 (51.5) | 0.045 | 0.215 |
Trastuzumab | Â | Â | Â | Â | Â | Â |
| Â | No | 340 (90.2) | 133 (39.1) | 207 (60.9) | Â | Â |
| Â | Yes | 37 (9.8) | 24 (64.9) | 13 (35.1) | 0.003 | 0.026 |