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Table 1 Biological categorization of MCF-7 proteins matched in the DAVID disease/cancer database (entries in italic are not all cancer markers, but were included in the list due to their functional relevance to the marker proteins)

From: Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle

ID

Protein name

MW

Total counts

Cancer

Breast cancer

Cell cycle/division/check-point/proliferation

    

O43684

BUB3_HUMAN Mitotic checkpoint protein BUB3

37131.2

78

Cancer

Breast cancer

P06400

RB_HUMAN Retinoblastoma-associated protein

106091.7

15

Cancer

Breast cancer

P12004

PCNA_HUMAN Proliferating cell nuclear antigen

28750.3

17

Cancer

 

P35232

PHB_HUMAN Prohibitin

29785.9

96

Cancer

Breast cancer

P78527

PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit

468786.9

889

Cancer

Breast cancer

P07437

TBB5_HUMAN Tubulin beta chain

49639

230

Cancer

Breast cancer

Q13509

TBB3_HUMAN Tubulin beta-3 chain

50400.3

127

Cancer

Breast cancer

Q14980

NUMA1_HUMAN Nuclear mitotic apparatus protein 1

238113.2

505

Cancer

Breast cancer

Q12888

TP53B_HUMAN Tumor suppressor p53-binding protein 1

213440.8

7

Cancer

Breast cancer

Q6P1J9

CDC73_HUMAN Parafibromin

60539.2

12

Cancer

 

P37231

PPARG_HUMAN Peroxisome proliferator-activated receptor gamma

57583.2

5

Cancer

Breast cancer

P46013

KI67_HUMAN Antigen KI-67

358471.9

50

  

P31947

1433S_HUMAN 14-3-3 protein sigma

27756.7

67

  

Q8IX12

CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1

132738.6

72

  

P06493

CDC2_HUMAN Cell division control protein 2 homolog

34073.9

20

  

P62136

PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

37487.8

179

  

P62140

PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit

37162.6

9

  

Q13616

CUL1_HUMAN Cullin-1

89622

12

  

Q13547

HDAC1_HUMAN Histone deacetylase 1

55067.8

120

  

Q92769

HDAC2_HUMAN Histone deacetylase 2

55328.8

31

  

Apoptosis

    

O14737

PDCD5_HUMAN Programmed cell death protein 5

14276.3

6

Cancer

 

Q07812

BAX_HUMAN Apoptosis regulator BAX

21170.8

1

Cancer

 

Q13153

PAK1_HUMAN Serine/threonine-protein kinase PAK 1

60608.8

4

Cancer

 

O43464

HTRA2_HUMAN Serine protease HTRA2, mitochondrial precursor

48811

5

  

O75340

PDCD6_HUMAN Programmed cell death protein 6

21854.8

103

  

O95831

AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial precursor

66859

57

  

P55957

BID_HUMAN BH3-interacting domain death agonist

21981.1

7

  

Q13158

FADD_HUMAN Protein FADD

23264.9

10

  

Q8IX12

CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1

132738.6

72

  

Q8N8D1

PDCD7_HUMAN Programmed cell death protein 7

54666.3

4

  

Q96IZ0

PAWR_HUMAN PRKC apoptosis WT1 regulator protein

36545.5

5

  

Q9BTC0

DIDO1_HUMAN Death-inducer obliterator 1

243720.8

76

  

Q9BZZ5

API5_HUMAN Apoptosis inhibitor 5

57525.2

75

  

Q9NR28

DBLOH_HUMAN Diablo homolog, mitochondrial precursor

27113.7

8

  

Q9NYF8

BCLF1_HUMAN Bcl-2-associated transcription factor 1

106058.7

80

  

Q9ULZ3

ASC_HUMAN Apoptosis-associated speck-like protein containing a CARD

21613.3

43

  

DNA Repair

    

O00255

MEN1_HUMAN Menin

67951

4

Cancer

 

P09874

PARP1_HUMAN Poly [ADP-ribose] polymerase 1

113012.4

342

Cancer

Breast cancer

P12004

PCNA_HUMAN Proliferating cell nuclear antigen

28750.3

17

Cancer

 

P12956

KU70_HUMAN ATP-dependent DNA helicase 2 subunit 1

69799.2

398

Cancer

Breast cancer

P13010

KU86_HUMAN ATP-dependent DNA helicase 2 subunit 2

82652.4

367

Cancer

Breast cancer

P16455

MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase

21632.2

22

Cancer

Breast cancer

P18074

ERCC2_HUMAN TFIIH basal transcription factor complex helicase subunit

86854.3

3

Cancer

Breast cancer

P18887

XRCC1_HUMAN DNA-repair protein XRCC1

69483.1

15

Cancer

Breast cancer

P20585

MSH3_HUMAN DNA mismatch repair protein Msh3

127376.1

5

Cancer

 

P27695

APEX1_HUMAN DNA-(apurinic or apyrimidinic site) lyase

35532.2

78

Cancer

Breast cancer

P29372

3MG_HUMAN DNA-3-methyladenine glycosylase

32842.8

36

Cancer

 

P35244

RFA3_HUMAN Replication protein A 14 kDa subunit

13559.9

29

Cancer

 

P43246

MSH2_HUMAN DNA mismatch repair protein Msh2

104676.8

21

Cancer

 

P46063

RECQ1_HUMAN ATP-dependent DNA helicase Q1

73409.1

10

Cancer

 

P49916

DNL3_HUMAN DNA ligase 3

102625.5

4

Cancer

Breast cancer

P52701

MSH6_HUMAN DNA mismatch repair protein MSH6

152688.4

37

Cancer

 

P54727

RD23B_HUMAN UV excision repair protein RAD23 homolog B

43144.6

78

Cancer

Breast cancer

P78527

PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit

468786.9

889

Cancer

Breast cancer

Q01831

XPC_HUMAN DNA-repair protein complementing XP-C cells

105915.3

14

Cancer

Breast cancer

Q12888

TP53B_HUMAN Tumor suppressor p53-binding protein 1

213440.8

7

Cancer

Breast cancer

Q92466

DDB2_HUMAN DNA damage-binding protein 2

47833.4

5

Cancer

 

Q92878

RAD50_HUMAN DNA repair protein RAD50

153795.8

11

Cancer

Breast cancer

Q9UBB5

MBD2_HUMAN Methyl-CpG-binding domain protein 2

43228

7

Cancer

Breast cancer

Q9UHN1

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial precursor

54876.3

7

Cancer

 

P39748

FEN1_HUMAN Flap endonuclease 1

42566.1

114

  

Angiogenesis

    

P13489

RINI_HUMAN Ribonuclease inhibitor

49941.2

17

Cancer

 

P40763

STAT3_HUMAN Signal transducer and activator of transcription 3

88011.4

13

Cancer

 

Q16539

MK14_HUMAN Mitogen-activated protein kinase 14

41267.1

2

  

Q14119

VEZF1_HUMAN Vascular endothelial zinc finger 1

56326.5

9

  

Q13685

AAMP_HUMAN Angio-associated migratory cell protein

46721.5

1

  

Q9UQB8

BAIP2_HUMAN Brain-specific angiogenesis inhibitor 1-associated protein

60829.7

5

  

Q92793

CBP_HUMAN CREB-binding protein

265180.1

2

  

Migration/invasion/adhesion/metastasis

    

P07858

CATB_HUMAN Cathepsin B precursor

37796.8

6

Cancer

 

P15941

MUC1_HUMAN Mucin-1 precursor

121999.6

4

Cancer

 

P17931

LEG3_HUMAN Galectin-3

26172.1

77

Cancer

 

P35222

CTNB1_HUMAN Catenin beta-1

85442.3

1

Cancer

 

P62328

TYB4_HUMAN Thymosin beta-4

5049.5

15

Cancer

 

Q06124

PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11

68393.4

2

Cancer

 

Q08380

LG3BP_HUMAN Galectin-3-binding protein precursor

65289.4

2

Cancer

 

Q13153

PAK1_HUMAN Serine/threonine-protein kinase PAK 1

60608.8

4

Cancer

 

Q13330

MTA1_HUMAN Metastasis-associated protein MTA1

80737.4

13

Cancer

Breast cancer

O60716

CTND1_HUMAN Catenin delta-1

108103.3

37

  

P07339

CATD_HUMAN Cathepsin D precursor

44523.7

105

  

P07355

ANXA2_HUMAN Annexin A2

38579.8

627

  

P09493

TPM1_HUMAN Tropomyosin alpha-1 chain

32688.7

91

  

P12814

ACTN1_HUMAN Alpha-actinin-1

102992.7

441

  

P23528

COF1_HUMAN Cofilin-1

18490.7

508

  

P35221

CTNA1_HUMAN Catenin alpha-1

100008.6

100

  

P35580

MYH10_HUMAN Myosin-10

228796.8

136

  

P60953

CDC42_HUMAN Cell division control protein 42 homolog precursor

21296.9

3

  

P61586

RHOA_HUMAN Transforming protein RhoA precursor

21754.1

12

  

P62258

1433E_HUMAN 14-3-3 protein epsilon

29155.4

136

  

P63000

RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 precursor

21436.3

9

  

Q07157

ZO1_HUMAN Tight junction protein ZO-1

195338.8

32

  

Q13418

ILK_HUMAN Integrin-linked protein kinase

51386

43

  

Q9UDY2

ZO2_HUMAN Tight junction protein ZO-2

133890.2

5

  

Q13685

AAMP_HUMAN Angio-associated migratory cell protein

46721.5

1

  

P08134

RHOC_HUMAN Rho-related GTP-binding protein RhoC precursor

21992.3

4

  

Differentiation

    

P15531

NDKA_HUMAN Nucleoside diphosphate kinase A

17137.7

154

Cancer

Breast cancer

P33076

C2TA_HUMAN MHC class II transactivator

123379.3

2

Cancer

 

O60869

EDF1_HUMAN Endothelial differentiation-related factor 1

16358.9

9

  

O95758

ROD1_HUMAN Regulator of differentiation 1

56466.5

15

  

P09382

LEG1_HUMAN Galectin-1

14706.2

7

  

P17931

LEG3_HUMAN Galectin-3

26172.1

77

Cancer

 

P23771

GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA3

47885.3

3

  

P35221

CTNA1_HUMAN Catenin alpha-1

100008.6

100

  

P37231

PPARG_HUMAN Peroxisome proliferator-activated receptor gamma

57583.2

5

Cancer

Breast cancer

P40763

STAT3_HUMAN Signal transducer and activator of transcription 3

88011.4

13

Cancer

 

Q8TB36

GDAP1_HUMAN Ganglioside-induced differentiation-associated protein 1

41225.8

2

  

Signaling

    

O00170

AIP_HUMAN AH receptor-interacting protein

37640.2

18

Cancer

Breast cancer

O14908

GIPC1_HUMAN PDZ domain-containing protein GIPC1

36026.7

34

Cancer

Breast cancer

P01112

RASH_HUMAN GTPase HRas precursor

21284.6

6

Cancer

Breast cancer

P02786

TFR1_HUMAN Transferrin receptor protein 1

84818

19

Cancer

Breast cancer

P08107

HSP71_HUMAN Heat shock 70 kDa protein 1

70009.2

560

Cancer

 

P11142

HSP7C_HUMAN Heat shock cognate 71 kDa protein

70854.4

895

Cancer

 

P15941

MUC1_HUMAN Mucin-1 precursor

121999.6

4

Cancer

 

P16615

AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

114682.7

8

Cancer

 

P29353

SHC1_HUMAN SHC-transforming protein 1

62812.6

8

Cancer

Breast cancer

P33076

C2TA_HUMAN MHC class II transactivator

123379.3

2

Cancer

 

P34931

HS71L_HUMAN Heat shock 70 kDa protein 1 L

70331.5

482

Cancer

 

P35222

CTNB1_HUMAN Catenin beta-1

85442.3

1

Cancer

 

P37231

PPARG_HUMAN Peroxisome proliferator-activated receptor gamma

57583.2

5

Cancer

Breast cancer

P40763

STAT3_HUMAN Signal transducer and activator of transcription 3

88011.4

13

Cancer

 

P78527

PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit

468786.9

889

Cancer

Breast cancer

Q04206

TF65_HUMAN Transcription factor p65

60181.6

2

Cancer

 

Q06124

PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11

68393.4

2

Cancer

 

Q07812

BAX_HUMAN Apoptosis regulator BAX

21170.8

1

Cancer

 

Q13085

COA1_HUMAN Acetyl-CoA carboxylase 1

265382.7

1

Cancer

Breast cancer

Q13153

PAK1_HUMAN Serine/threonine-protein kinase PAK 1

60608.8

4

Cancer

 

Q14653

IRF3_HUMAN Interferon regulatory factor 3

47189.7

2

Cancer

 

Q15796

SMAD2_HUMAN Mothers against decapentaplegic homolog 2

52272.8

1

Cancer

 

Q5JWF2

GNAS1_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

110955.6

67

Cancer

Breast cancer

Q7LG56

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

40710.5

5

Cancer

 

Q8WUF5

IASPP_HUMAN RelA-associated inhibitor

89036

15

Cancer

 

Q92466

DDB2_HUMAN DNA damage-binding protein 2

47833.4

5

Cancer

 

Q96RG5

Q96RG5_HUMAN Insulin receptor substrate 2 insertion mutant

137347.9

1

Cancer

Breast cancer

P31947

1433S_HUMAN 14-3-3 protein sigma

27756.7

67

  

P62993

GRB2_HUMAN Growth factor receptor-bound protein 2

25190.4

32

  

P46108

CRK_HUMAN Proto-oncogene C-crk

33810

18

  

Q16539

MK14_HUMAN Mitogen-activated protein kinase 14

41267.1

2

  

P42224

STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/be

87279.6

62

  

Q13547

HDAC1_HUMAN Histone deacetylase 1

55067.8

120

  

Q92769

HDAC2_HUMAN Histone deacetylase 2

55328.8

31

  

P56545

CTBP2_HUMAN C-terminal-binding protein 2

48914.2

26

  

Q13363

CTBP1_HUMAN C-terminal-binding protein 1

47505.6

8

  

Q92793

CBP_HUMAN CREB-binding protein

265180.1

2

  

Q13616

CUL1_HUMAN Cullin-1

89622

12

  

P62136

PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

37487.8

179

  

P62140

PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit

37162.6

9

  

P06493

CDC2_HUMAN Cell division control protein 2 homolog

34073.9

20

  

P61586

RHOA_HUMAN Transforming protein RhoA precursor

21754.1

12

  

P08134

RHOC_HUMAN Rho-related GTP-binding protein RhoC precursor

21992.3

4

  

Oxidative processes/redox

    

P00441

SODC_HUMAN Superoxide dismutase [Cu-Zn]

15925.9

35

Cancer

Breast cancer

P03891

NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2

38934.8

4

Cancer

Breast cancer

P04040

CATA_HUMAN Catalase

59718.9

3

Cancer

Breast cancer

P04179

SODM_HUMAN Superoxide dismutase [Mn], mitochondrial precursor

24706.6

1

Cancer

Breast cancer

P10599

THIO_HUMAN Thioredoxin

11729.7

28

Cancer

Breast cancer

P15559

NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1

30848

40

Cancer

Breast cancer

P16435

NCPR_HUMAN NADPH--cytochrome P450 reductase

76641.4

22

Cancer

Breast cancer

P21912

DHSB_HUMAN Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

31608.9

5

Cancer

 

P47985

UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor

29649.4

2

Cancer

Breast cancer

Q99757

THIOM_HUMAN Thioredoxin, mitochondrial precursor

18371.6

1

Cancer

Breast cancer

Q07973

CP24A_HUMAN Cytochrome P450 24A1, mitochondrial precursor

58837.6

15

Cancer

Breast cancer

P30041

PRDX6_HUMAN Peroxiredoxin-6

25019.2

150

  

P30044

PRDX5_HUMAN Peroxiredoxin-5, mitochondrial precursor

22012.5

110

  

P30048

PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial precursor

27675.2

48

  

P32119

PRDX2_HUMAN Peroxiredoxin-2

21878.2

102

  

Q06830

PRDX1_HUMAN Peroxiredoxin-1

22096.3

191

  

Various metabolic functions and DNA/RNA processing

    

O43708

MAAI_HUMAN Maleylacetoacetate isomerase

24166.7

4

Cancer

Breast cancer

P00390

GSHR_HUMAN Glutathione reductase, mitochondrial precursor

56221

1

Cancer

Breast cancer

P00492

HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase

24563.6

32

Cancer

 

P00558

PGK1_HUMAN Phosphoglycerate kinase 1

44586.2

466

Cancer

 

P07099

HYEP_HUMAN Epoxide hydrolase 1

52915

9

Cancer

Breast cancer

P11172

PYR5_HUMAN Uridine 5'-monophosphate synthase

52188.7

11

Cancer

 

P11586

C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic

101495.6

149

Cancer

Breast cancer

P15531

NDKA_HUMAN Nucleoside diphosphate kinase A

17137.7

154

Cancer

Breast cancer

P21266

GSTM3_HUMAN Glutathione S-transferase Mu 3

26542.2

59

Cancer

Breast cancer

P21964

COMT_HUMAN Catechol O-methyltransferase

30017.6

35

Cancer

Breast cancer

P23921

RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit

90012.5

4

Cancer

Breast cancer

P30876

RPB2_HUMAN DNA-directed RNA polymerase II subunit RPB2

133810.7

2

Cancer

 

P34896

GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic

53049.1

23

Cancer

Breast cancer

P35520

CBS_HUMAN Cystathionine beta-synthase

60548.3

9

Cancer

Breast cancer

P61604

CH10_HUMAN 10 kDa heat shock protein, mitochondrial

10924.9

58

Cancer

 

P78417

GSTO1_HUMAN Glutathione transferase omega-1

27548

16

Cancer

Breast cancer

Q07973

CP24A_HUMAN Cytochrome P450 24A1, mitochondrial precursor

58837.6

15

Cancer

Breast cancer

Q13085

COA1_HUMAN Acetyl-CoA carboxylase 1

265382.7

1

Cancer

Breast cancer

Q7LG56

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

40710.5

5

Cancer

 

Q7Z5J4

RAI1_HUMAN Retinoic acid-induced protein 1

203223.9

11

Cancer

 

Q92820

GGH_HUMAN Gamma-glutamyl hydrolase precursor

35941.2

17

Cancer

 

Q9UBB5

MBD2_HUMAN Methyl-CpG-binding domain protein 2

43228

7

Cancer

Breast cancer

Q9UHN1

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial precursor

54876.3

7

Cancer

 

Cytoskeleton organization

    

P07437

TBB5_HUMAN Tubulin beta chain

49639

230

Cancer

Breast cancer

P62328

TYB4_HUMAN Thymosin beta-4

5049.5

15

Cancer

 

Q13509

TBB3_HUMAN Tubulin beta-3 chain

50400.3

127

Cancer

Breast cancer

Q14980

NUMA1_HUMAN Nuclear mitotic apparatus protein 1

238113.2

505

Cancer

Breast cancer

Q92747

ARC1A_HUMAN Actin-related protein 2/3 complex subunit 1A

41542.7

1

Cancer

 

Transport/trafficking

    

O14908

GIPC1_HUMAN PDZ domain-containing protein GIPC1

36026.7

34

Cancer

Breast cancer

O75915

PRAF3_HUMAN PRA1 family protein 3

21600.4

19

Cancer

 

Q8N1B4

VPS52_HUMAN Vacuolar protein sorting-associated protein 52 homolog

82169.8

14

Cancer

Â