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Table 1 Biological categorization of MCF-7 proteins matched in the DAVID disease/cancer database (entries in italic are not all cancer markers, but were included in the list due to their functional relevance to the marker proteins)

From: Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle

ID Protein name MW Total counts Cancer Breast cancer
Cell cycle/division/check-point/proliferation     
O43684 BUB3_HUMAN Mitotic checkpoint protein BUB3 37131.2 78 Cancer Breast cancer
P06400 RB_HUMAN Retinoblastoma-associated protein 106091.7 15 Cancer Breast cancer
P12004 PCNA_HUMAN Proliferating cell nuclear antigen 28750.3 17 Cancer  
P35232 PHB_HUMAN Prohibitin 29785.9 96 Cancer Breast cancer
P78527 PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit 468786.9 889 Cancer Breast cancer
P07437 TBB5_HUMAN Tubulin beta chain 49639 230 Cancer Breast cancer
Q13509 TBB3_HUMAN Tubulin beta-3 chain 50400.3 127 Cancer Breast cancer
Q14980 NUMA1_HUMAN Nuclear mitotic apparatus protein 1 238113.2 505 Cancer Breast cancer
Q12888 TP53B_HUMAN Tumor suppressor p53-binding protein 1 213440.8 7 Cancer Breast cancer
Q6P1J9 CDC73_HUMAN Parafibromin 60539.2 12 Cancer  
P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma 57583.2 5 Cancer Breast cancer
P46013 KI67_HUMAN Antigen KI-67 358471.9 50   
P31947 1433S_HUMAN 14-3-3 protein sigma 27756.7 67   
Q8IX12 CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 132738.6 72   
P06493 CDC2_HUMAN Cell division control protein 2 homolog 34073.9 20   
P62136 PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 37487.8 179   
P62140 PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit 37162.6 9   
Q13616 CUL1_HUMAN Cullin-1 89622 12   
Q13547 HDAC1_HUMAN Histone deacetylase 1 55067.8 120   
Q92769 HDAC2_HUMAN Histone deacetylase 2 55328.8 31   
Apoptosis     
O14737 PDCD5_HUMAN Programmed cell death protein 5 14276.3 6 Cancer  
Q07812 BAX_HUMAN Apoptosis regulator BAX 21170.8 1 Cancer  
Q13153 PAK1_HUMAN Serine/threonine-protein kinase PAK 1 60608.8 4 Cancer  
O43464 HTRA2_HUMAN Serine protease HTRA2, mitochondrial precursor 48811 5   
O75340 PDCD6_HUMAN Programmed cell death protein 6 21854.8 103   
O95831 AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial precursor 66859 57   
P55957 BID_HUMAN BH3-interacting domain death agonist 21981.1 7   
Q13158 FADD_HUMAN Protein FADD 23264.9 10   
Q8IX12 CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 132738.6 72   
Q8N8D1 PDCD7_HUMAN Programmed cell death protein 7 54666.3 4   
Q96IZ0 PAWR_HUMAN PRKC apoptosis WT1 regulator protein 36545.5 5   
Q9BTC0 DIDO1_HUMAN Death-inducer obliterator 1 243720.8 76   
Q9BZZ5 API5_HUMAN Apoptosis inhibitor 5 57525.2 75   
Q9NR28 DBLOH_HUMAN Diablo homolog, mitochondrial precursor 27113.7 8   
Q9NYF8 BCLF1_HUMAN Bcl-2-associated transcription factor 1 106058.7 80   
Q9ULZ3 ASC_HUMAN Apoptosis-associated speck-like protein containing a CARD 21613.3 43   
DNA Repair     
O00255 MEN1_HUMAN Menin 67951 4 Cancer  
P09874 PARP1_HUMAN Poly [ADP-ribose] polymerase 1 113012.4 342 Cancer Breast cancer
P12004 PCNA_HUMAN Proliferating cell nuclear antigen 28750.3 17 Cancer  
P12956 KU70_HUMAN ATP-dependent DNA helicase 2 subunit 1 69799.2 398 Cancer Breast cancer
P13010 KU86_HUMAN ATP-dependent DNA helicase 2 subunit 2 82652.4 367 Cancer Breast cancer
P16455 MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase 21632.2 22 Cancer Breast cancer
P18074 ERCC2_HUMAN TFIIH basal transcription factor complex helicase subunit 86854.3 3 Cancer Breast cancer
P18887 XRCC1_HUMAN DNA-repair protein XRCC1 69483.1 15 Cancer Breast cancer
P20585 MSH3_HUMAN DNA mismatch repair protein Msh3 127376.1 5 Cancer  
P27695 APEX1_HUMAN DNA-(apurinic or apyrimidinic site) lyase 35532.2 78 Cancer Breast cancer
P29372 3MG_HUMAN DNA-3-methyladenine glycosylase 32842.8 36 Cancer  
P35244 RFA3_HUMAN Replication protein A 14 kDa subunit 13559.9 29 Cancer  
P43246 MSH2_HUMAN DNA mismatch repair protein Msh2 104676.8 21 Cancer  
P46063 RECQ1_HUMAN ATP-dependent DNA helicase Q1 73409.1 10 Cancer  
P49916 DNL3_HUMAN DNA ligase 3 102625.5 4 Cancer Breast cancer
P52701 MSH6_HUMAN DNA mismatch repair protein MSH6 152688.4 37 Cancer  
P54727 RD23B_HUMAN UV excision repair protein RAD23 homolog B 43144.6 78 Cancer Breast cancer
P78527 PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit 468786.9 889 Cancer Breast cancer
Q01831 XPC_HUMAN DNA-repair protein complementing XP-C cells 105915.3 14 Cancer Breast cancer
Q12888 TP53B_HUMAN Tumor suppressor p53-binding protein 1 213440.8 7 Cancer Breast cancer
Q92466 DDB2_HUMAN DNA damage-binding protein 2 47833.4 5 Cancer  
Q92878 RAD50_HUMAN DNA repair protein RAD50 153795.8 11 Cancer Breast cancer
Q9UBB5 MBD2_HUMAN Methyl-CpG-binding domain protein 2 43228 7 Cancer Breast cancer
Q9UHN1 DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial precursor 54876.3 7 Cancer  
P39748 FEN1_HUMAN Flap endonuclease 1 42566.1 114   
Angiogenesis     
P13489 RINI_HUMAN Ribonuclease inhibitor 49941.2 17 Cancer  
P40763 STAT3_HUMAN Signal transducer and activator of transcription 3 88011.4 13 Cancer  
Q16539 MK14_HUMAN Mitogen-activated protein kinase 14 41267.1 2   
Q14119 VEZF1_HUMAN Vascular endothelial zinc finger 1 56326.5 9   
Q13685 AAMP_HUMAN Angio-associated migratory cell protein 46721.5 1   
Q9UQB8 BAIP2_HUMAN Brain-specific angiogenesis inhibitor 1-associated protein 60829.7 5   
Q92793 CBP_HUMAN CREB-binding protein 265180.1 2   
Migration/invasion/adhesion/metastasis     
P07858 CATB_HUMAN Cathepsin B precursor 37796.8 6 Cancer  
P15941 MUC1_HUMAN Mucin-1 precursor 121999.6 4 Cancer  
P17931 LEG3_HUMAN Galectin-3 26172.1 77 Cancer  
P35222 CTNB1_HUMAN Catenin beta-1 85442.3 1 Cancer  
P62328 TYB4_HUMAN Thymosin beta-4 5049.5 15 Cancer  
Q06124 PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 68393.4 2 Cancer  
Q08380 LG3BP_HUMAN Galectin-3-binding protein precursor 65289.4 2 Cancer  
Q13153 PAK1_HUMAN Serine/threonine-protein kinase PAK 1 60608.8 4 Cancer  
Q13330 MTA1_HUMAN Metastasis-associated protein MTA1 80737.4 13 Cancer Breast cancer
O60716 CTND1_HUMAN Catenin delta-1 108103.3 37   
P07339 CATD_HUMAN Cathepsin D precursor 44523.7 105   
P07355 ANXA2_HUMAN Annexin A2 38579.8 627   
P09493 TPM1_HUMAN Tropomyosin alpha-1 chain 32688.7 91   
P12814 ACTN1_HUMAN Alpha-actinin-1 102992.7 441   
P23528 COF1_HUMAN Cofilin-1 18490.7 508   
P35221 CTNA1_HUMAN Catenin alpha-1 100008.6 100   
P35580 MYH10_HUMAN Myosin-10 228796.8 136   
P60953 CDC42_HUMAN Cell division control protein 42 homolog precursor 21296.9 3   
P61586 RHOA_HUMAN Transforming protein RhoA precursor 21754.1 12   
P62258 1433E_HUMAN 14-3-3 protein epsilon 29155.4 136   
P63000 RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 precursor 21436.3 9   
Q07157 ZO1_HUMAN Tight junction protein ZO-1 195338.8 32   
Q13418 ILK_HUMAN Integrin-linked protein kinase 51386 43   
Q9UDY2 ZO2_HUMAN Tight junction protein ZO-2 133890.2 5   
Q13685 AAMP_HUMAN Angio-associated migratory cell protein 46721.5 1   
P08134 RHOC_HUMAN Rho-related GTP-binding protein RhoC precursor 21992.3 4   
Differentiation     
P15531 NDKA_HUMAN Nucleoside diphosphate kinase A 17137.7 154 Cancer Breast cancer
P33076 C2TA_HUMAN MHC class II transactivator 123379.3 2 Cancer  
O60869 EDF1_HUMAN Endothelial differentiation-related factor 1 16358.9 9   
O95758 ROD1_HUMAN Regulator of differentiation 1 56466.5 15   
P09382 LEG1_HUMAN Galectin-1 14706.2 7   
P17931 LEG3_HUMAN Galectin-3 26172.1 77 Cancer  
P23771 GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA3 47885.3 3   
P35221 CTNA1_HUMAN Catenin alpha-1 100008.6 100   
P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma 57583.2 5 Cancer Breast cancer
P40763 STAT3_HUMAN Signal transducer and activator of transcription 3 88011.4 13 Cancer  
Q8TB36 GDAP1_HUMAN Ganglioside-induced differentiation-associated protein 1 41225.8 2   
Signaling     
O00170 AIP_HUMAN AH receptor-interacting protein 37640.2 18 Cancer Breast cancer
O14908 GIPC1_HUMAN PDZ domain-containing protein GIPC1 36026.7 34 Cancer Breast cancer
P01112 RASH_HUMAN GTPase HRas precursor 21284.6 6 Cancer Breast cancer
P02786 TFR1_HUMAN Transferrin receptor protein 1 84818 19 Cancer Breast cancer
P08107 HSP71_HUMAN Heat shock 70 kDa protein 1 70009.2 560 Cancer  
P11142 HSP7C_HUMAN Heat shock cognate 71 kDa protein 70854.4 895 Cancer  
P15941 MUC1_HUMAN Mucin-1 precursor 121999.6 4 Cancer  
P16615 AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 114682.7 8 Cancer  
P29353 SHC1_HUMAN SHC-transforming protein 1 62812.6 8 Cancer Breast cancer
P33076 C2TA_HUMAN MHC class II transactivator 123379.3 2 Cancer  
P34931 HS71L_HUMAN Heat shock 70 kDa protein 1 L 70331.5 482 Cancer  
P35222 CTNB1_HUMAN Catenin beta-1 85442.3 1 Cancer  
P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma 57583.2 5 Cancer Breast cancer
P40763 STAT3_HUMAN Signal transducer and activator of transcription 3 88011.4 13 Cancer  
P78527 PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit 468786.9 889 Cancer Breast cancer
Q04206 TF65_HUMAN Transcription factor p65 60181.6 2 Cancer  
Q06124 PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 68393.4 2 Cancer  
Q07812 BAX_HUMAN Apoptosis regulator BAX 21170.8 1 Cancer  
Q13085 COA1_HUMAN Acetyl-CoA carboxylase 1 265382.7 1 Cancer Breast cancer
Q13153 PAK1_HUMAN Serine/threonine-protein kinase PAK 1 60608.8 4 Cancer  
Q14653 IRF3_HUMAN Interferon regulatory factor 3 47189.7 2 Cancer  
Q15796 SMAD2_HUMAN Mothers against decapentaplegic homolog 2 52272.8 1 Cancer  
Q5JWF2 GNAS1_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 110955.6 67 Cancer Breast cancer
Q7LG56 RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B 40710.5 5 Cancer  
Q8WUF5 IASPP_HUMAN RelA-associated inhibitor 89036 15 Cancer  
Q92466 DDB2_HUMAN DNA damage-binding protein 2 47833.4 5 Cancer  
Q96RG5 Q96RG5_HUMAN Insulin receptor substrate 2 insertion mutant 137347.9 1 Cancer Breast cancer
P31947 1433S_HUMAN 14-3-3 protein sigma 27756.7 67   
P62993 GRB2_HUMAN Growth factor receptor-bound protein 2 25190.4 32   
P46108 CRK_HUMAN Proto-oncogene C-crk 33810 18   
Q16539 MK14_HUMAN Mitogen-activated protein kinase 14 41267.1 2   
P42224 STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/be 87279.6 62   
Q13547 HDAC1_HUMAN Histone deacetylase 1 55067.8 120   
Q92769 HDAC2_HUMAN Histone deacetylase 2 55328.8 31   
P56545 CTBP2_HUMAN C-terminal-binding protein 2 48914.2 26   
Q13363 CTBP1_HUMAN C-terminal-binding protein 1 47505.6 8   
Q92793 CBP_HUMAN CREB-binding protein 265180.1 2   
Q13616 CUL1_HUMAN Cullin-1 89622 12   
P62136 PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 37487.8 179   
P62140 PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit 37162.6 9   
P06493 CDC2_HUMAN Cell division control protein 2 homolog 34073.9 20   
P61586 RHOA_HUMAN Transforming protein RhoA precursor 21754.1 12   
P08134 RHOC_HUMAN Rho-related GTP-binding protein RhoC precursor 21992.3 4   
Oxidative processes/redox     
P00441 SODC_HUMAN Superoxide dismutase [Cu-Zn] 15925.9 35 Cancer Breast cancer
P03891 NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 38934.8 4 Cancer Breast cancer
P04040 CATA_HUMAN Catalase 59718.9 3 Cancer Breast cancer
P04179 SODM_HUMAN Superoxide dismutase [Mn], mitochondrial precursor 24706.6 1 Cancer Breast cancer
P10599 THIO_HUMAN Thioredoxin 11729.7 28 Cancer Breast cancer
P15559 NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 30848 40 Cancer Breast cancer
P16435 NCPR_HUMAN NADPH--cytochrome P450 reductase 76641.4 22 Cancer Breast cancer
P21912 DHSB_HUMAN Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 31608.9 5 Cancer  
P47985 UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor 29649.4 2 Cancer Breast cancer
Q99757 THIOM_HUMAN Thioredoxin, mitochondrial precursor 18371.6 1 Cancer Breast cancer
Q07973 CP24A_HUMAN Cytochrome P450 24A1, mitochondrial precursor 58837.6 15 Cancer Breast cancer
P30041 PRDX6_HUMAN Peroxiredoxin-6 25019.2 150   
P30044 PRDX5_HUMAN Peroxiredoxin-5, mitochondrial precursor 22012.5 110   
P30048 PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial precursor 27675.2 48   
P32119 PRDX2_HUMAN Peroxiredoxin-2 21878.2 102   
Q06830 PRDX1_HUMAN Peroxiredoxin-1 22096.3 191   
Various metabolic functions and DNA/RNA processing     
O43708 MAAI_HUMAN Maleylacetoacetate isomerase 24166.7 4 Cancer Breast cancer
P00390 GSHR_HUMAN Glutathione reductase, mitochondrial precursor 56221 1 Cancer Breast cancer
P00492 HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase 24563.6 32 Cancer  
P00558 PGK1_HUMAN Phosphoglycerate kinase 1 44586.2 466 Cancer  
P07099 HYEP_HUMAN Epoxide hydrolase 1 52915 9 Cancer Breast cancer
P11172 PYR5_HUMAN Uridine 5'-monophosphate synthase 52188.7 11 Cancer  
P11586 C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic 101495.6 149 Cancer Breast cancer
P15531 NDKA_HUMAN Nucleoside diphosphate kinase A 17137.7 154 Cancer Breast cancer
P21266 GSTM3_HUMAN Glutathione S-transferase Mu 3 26542.2 59 Cancer Breast cancer
P21964 COMT_HUMAN Catechol O-methyltransferase 30017.6 35 Cancer Breast cancer
P23921 RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit 90012.5 4 Cancer Breast cancer
P30876 RPB2_HUMAN DNA-directed RNA polymerase II subunit RPB2 133810.7 2 Cancer  
P34896 GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic 53049.1 23 Cancer Breast cancer
P35520 CBS_HUMAN Cystathionine beta-synthase 60548.3 9 Cancer Breast cancer
P61604 CH10_HUMAN 10 kDa heat shock protein, mitochondrial 10924.9 58 Cancer  
P78417 GSTO1_HUMAN Glutathione transferase omega-1 27548 16 Cancer Breast cancer
Q07973 CP24A_HUMAN Cytochrome P450 24A1, mitochondrial precursor 58837.6 15 Cancer Breast cancer
Q13085 COA1_HUMAN Acetyl-CoA carboxylase 1 265382.7 1 Cancer Breast cancer
Q7LG56 RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B 40710.5 5 Cancer  
Q7Z5J4 RAI1_HUMAN Retinoic acid-induced protein 1 203223.9 11 Cancer  
Q92820 GGH_HUMAN Gamma-glutamyl hydrolase precursor 35941.2 17 Cancer  
Q9UBB5 MBD2_HUMAN Methyl-CpG-binding domain protein 2 43228 7 Cancer Breast cancer
Q9UHN1 DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial precursor 54876.3 7 Cancer  
Cytoskeleton organization     
P07437 TBB5_HUMAN Tubulin beta chain 49639 230 Cancer Breast cancer
P62328 TYB4_HUMAN Thymosin beta-4 5049.5 15 Cancer  
Q13509 TBB3_HUMAN Tubulin beta-3 chain 50400.3 127 Cancer Breast cancer
Q14980 NUMA1_HUMAN Nuclear mitotic apparatus protein 1 238113.2 505 Cancer Breast cancer
Q92747 ARC1A_HUMAN Actin-related protein 2/3 complex subunit 1A 41542.7 1 Cancer  
Transport/trafficking     
O14908 GIPC1_HUMAN PDZ domain-containing protein GIPC1 36026.7 34 Cancer Breast cancer
O75915 PRAF3_HUMAN PRA1 family protein 3 21600.4 19 Cancer  
Q8N1B4 VPS52_HUMAN Vacuolar protein sorting-associated protein 52 homolog 82169.8 14 Cancer