Figure 3

Investigation of E-cadherin and N-cadherin expression in non-small cell lung cancer (T) and lung tissues (N) using immunohistochemistry. Strong and entire membrane expression of E-cadherin was seen in normal bronchial epithelium. Membrane expression of E-cadherin was decreased in cancer cells. N-cadherin expression was commonly absent in normal bronchial epithelium. Diffuse cytoplasmic expression of N-cadherin was detected in cancer cells. Strong cytoplasmic Btbd7 expression was accompanied by reduced membrane E-cadherin expression and accumulation of N-cadherin in cytoplasm in cancer cells (×400).