Table 1 Univariate and multivariate analysis of clinical, pathological and molecular variables for disease-specific survival in 214 HCC

Cirrhosis

1.45

0.90-2.31

0.119

-

-

-

Multiple tumors

1.952

1.09-3.49

0.024

3.53

1.83-6.81

0.000167

HCC > 5 cm

1.705

1.04-2.80

0.035

1.88

1.01-3.47

0.044943

AFP > 20 ng/ml

2.04

1.25-3.32

0.0043

1.58

0.90-2.76

0.107818

Microvascular invasion

2.98

1.86-4.78

5.83e-06

1.98

1.09-3.60

0.024328

Tumor portal thrombosis

3.59

2.14-6.01

1.21e-06

1.92

1.01-3.66

0.045599

Differentiation: Edmonson III/IV

1.60

1.01-2.52

0.0436

0.88

0.50-1.54

0.653579

PI4KA high level

2.22

1.39-3.54

0.000823

2.36

1.27-4.36

0.006415