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Table 1 Characteristics of the patients and measured biomarkers

From: Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

Variable Normal Benign Borderline Carcinoma P
Total 31 (100) 38 (100) 18 (100) 75 (100)  
Median age [range] at diagnosis, years 60 [36–81] 57 [16–92] 66 [20–92] 59 [26–83] 0.248
Histologic subtype      
Serous   22 (59) 12 (67) 49 (65)  
Mucinous   15 (41) 6 (33) 8 (11)  
Endometroid     15 (20)  
Clear cell     3 (4)  
Ang-1 (median, ng/mL) 23.1 [20.1-33.2] 29.4 [20.6-37.7] 24.0 [16.6-43.0] 31.0 [24.0-42.3] 0.035
Ang-2 (median, ng/mL) 1.5 [1.1-2.2] 1.9 [1.3-2.2] 1.6 [1.4-3.1] 2.7 [1.8-3.5] <0.001
sVEGFR-1 (median, ng/mL) 0.13 [0.11-0.16] 0.11 [0.11-0.14] 0.11 [0.10-0.13] 0.13 [0.11-0.14] 0.062
sVEGFR-2 (median, ng/mL) 8.4 [6.6-11.7] 7.3 [6.4-8.4] 7.5 [6.3-8.7] 7.1 [5.8-8.3] 0.015
sVEGFR-3 (median, ng/mL) 30.7 [24.1-43.1] 31.3 [26.4-38.4] 30.0 [23.8-37.7] 31.2 [22.6-42.0] 0.888
VEGF-A (median, ng/mL) 0.31 [0.22-0.46] 0.24 [0.11-0.50] 0.28 [0.16-0.52] 0.43 [0.19-0.74] 0.033
VEGF-C (median, ng/mL) 7.4 [5.8-9.0] 8.0 [5.5-12.8] 9.8 [7.5-10.7] 7.0 [5.2-9.3] 0.129
VEGF-D (median, ng/mL) 0.29 [0.18-0.47] 0.33 [0.20-0.79] 0.58 [0.37-0.76] 0.46 [0.34-0.60] 0.002
VEGF-A/sVEGFR-2 (median, ng/mL) 0.04 [0.00-0.14] 0.03 [0.01-0.30] 0.04 [0.01-0.06] 0.05 [0.01-0.34] 0.011
Ang-2/VEGF-A (median, ng/mL) 4.9 [1.66-47.2] 8.4 [1.2-40.6] 6.8 [2.4-51.0] 7.6 [1.2-41.4] 0.673
Ang-2/sVEGFR-2      
(median, ng/mL) 0.17 [0.07-0.69] 0.24 [0.12-0.63] 0.25 [0.12-0.67] 0.37 [0.15-1.5] <0.001
CA125 (median, kU/l) 10 [7-16] 11 [8-18] 16 [9–82] 586 [124–1368] <0.001
  1. Values are n (%) unless stated otherwise.
  2. Values in square brackets indicate 25–75 quartiles unless stated otherwise.
  3. P value = Kruskall Wallis test.