Variable | Normal | Benign | Borderline | Carcinoma | P |
---|---|---|---|---|---|
Total | 31 (100) | 38 (100) | 18 (100) | 75 (100) | Â |
Median age [range] at diagnosis, years | 60 [36–81] | 57 [16–92] | 66 [20–92] | 59 [26–83] | 0.248 |
Histologic subtype | Â | Â | Â | Â | Â |
Serous | Â | 22 (59) | 12 (67) | 49 (65) | Â |
Mucinous | Â | 15 (41) | 6 (33) | 8 (11) | Â |
Endometroid | Â | Â | Â | 15 (20) | Â |
Clear cell | Â | Â | Â | 3 (4) | Â |
Ang-1 (median, ng/mL) | 23.1 [20.1-33.2] | 29.4 [20.6-37.7] | 24.0 [16.6-43.0] | 31.0 [24.0-42.3] | 0.035 |
Ang-2 (median, ng/mL) | 1.5 [1.1-2.2] | 1.9 [1.3-2.2] | 1.6 [1.4-3.1] | 2.7 [1.8-3.5] | <0.001 |
sVEGFR-1 (median, ng/mL) | 0.13 [0.11-0.16] | 0.11 [0.11-0.14] | 0.11 [0.10-0.13] | 0.13 [0.11-0.14] | 0.062 |
sVEGFR-2 (median, ng/mL) | 8.4 [6.6-11.7] | 7.3 [6.4-8.4] | 7.5 [6.3-8.7] | 7.1 [5.8-8.3] | 0.015 |
sVEGFR-3 (median, ng/mL) | 30.7 [24.1-43.1] | 31.3 [26.4-38.4] | 30.0 [23.8-37.7] | 31.2 [22.6-42.0] | 0.888 |
VEGF-A (median, ng/mL) | 0.31 [0.22-0.46] | 0.24 [0.11-0.50] | 0.28 [0.16-0.52] | 0.43 [0.19-0.74] | 0.033 |
VEGF-C (median, ng/mL) | 7.4 [5.8-9.0] | 8.0 [5.5-12.8] | 9.8 [7.5-10.7] | 7.0 [5.2-9.3] | 0.129 |
VEGF-D (median, ng/mL) | 0.29 [0.18-0.47] | 0.33 [0.20-0.79] | 0.58 [0.37-0.76] | 0.46 [0.34-0.60] | 0.002 |
VEGF-A/sVEGFR-2 (median, ng/mL) | 0.04 [0.00-0.14] | 0.03 [0.01-0.30] | 0.04 [0.01-0.06] | 0.05 [0.01-0.34] | 0.011 |
Ang-2/VEGF-A (median, ng/mL) | 4.9 [1.66-47.2] | 8.4 [1.2-40.6] | 6.8 [2.4-51.0] | 7.6 [1.2-41.4] | 0.673 |
Ang-2/sVEGFR-2 | Â | Â | Â | Â | Â |
(median, ng/mL) | 0.17 [0.07-0.69] | 0.24 [0.12-0.63] | 0.25 [0.12-0.67] | 0.37 [0.15-1.5] | <0.001 |
CA125 (median, kU/l) | 10 [7-16] | 11 [8-18] | 16 [9–82] | 586 [124–1368] | <0.001 |