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Table 1 Factors predicting malignant behavior (8, 11)

From: Paraneoplastic brainstem encephalitis in a patient with exceptionally long course of a metastasized neuroendocrine rectum neoplasm

Predictive factor  
Tumor size > than 20 mm
Mitotic index >2/10 high power fields
Muscularis layer invasion --
Lymphovascular invasion --