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Figure 7 | BMC Cancer

Figure 7

From: Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling

Figure 7

The effect of ADI in combination with PI3K inhibitor LY294002 on PI3K/Akt survival signal pathway. Protein expression levels of phosphorylated and total levels of Akt, p65, Erk1/2 along with PI3KCA and B-actin were detected in A, PANC-1 cells and B, BxPC-3 cells treated with or without ADI and LY294002. The combined treatment significantly reduced p-Akt and p-p65 expression in PANC-1, but not BxPC-3 cells, as shown in the densitometry graphs. *, P < 0.05, as compared with the control group; #, P < 0.05, as compared with the indicated groups; NS, not significant.

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