Figure 1

Strategy for screening a kinase specific compound library in multidrug resistant osteosarcoma cell lines. The kinase inhibitor screening was performed at the concentration of 0.66 μM and 1.8 μM with or without the presence of paclitaxel (0.1 μM) or doxorubicin (0.5 μM) in a four-day cellular proliferation assay. The combinatory drug effect was measured via CellTiter-Glo® Luminescent Cell Viability Assay Kit as described in Methods. Red: no effect on drug sensitivities; green: minor effect on drug sensitivities; blue: significant effect on drug sensitivities.