Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case–control study

BMC Cancer

Table 3 mtDNA copy number and glioma risk estimates by selected variables

Variables	Cases^a(n)		Controls^a(n)		Adjusted OR^b(95% CI)	Pvalue
Variables	High	Low	High	Low	Adjusted OR^b(95% CI)	Pvalue
Sex
Male	198	43	122	119	4.85 (3.52 to 6.71)	<0.001
Female	139	34	86	87	4.26 (2.83 to 5.94)	<0.001
Age, years
<47	167	37	103	103	4.81 (3.42 to 6.69)	<0.001
≥47	170	40	105	103	4.84 (3.59 to 6.65)	<0.001
Smoking status
Never	275	43	166	163	4.92 (3.43 to 6.82)	<0.001
Ever	62	34	42	43	1.98 (1.14 to 3.02)	0.014
Family history of cancer
Yes	28	17	16	16	2.14 (1.19 to 3.36)	0.006
No	309	60	192	190	4.89 (3.36 to 6.84)	<0.001

95% CI, 95% confidence interval; mtDNA, mitochondrial DNA; OR, odds ratio.
^aCases and controls were dichotomized based on the median value of controls.
^bAdjusted by age, sex, smoking status, family history of cancer and histology type where appropriate.

ISSN: 1471-2407