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Table 2 χ2 tests for identification of prognostic factors for metastasis

From: Postoperative nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma

Candidate Metastasis positive (%) Metastasis free (%) P
Sex Male 21 (42.0) 29 (58.0) 0.31
  Female 13 (31.7) 28 (68.3)  
Age ≤ 14 years 12 (33.3) 24 (66.7) 0.52
  > 15 years 22 (40.0) 33 (60.0)  
Tumor site Distal femur/Proximal tibia/Proximal humerus (Not exceeding the isthmus) 12 (21.1) 45 (78.9) <0.001
  Others 22 (67.4) 12 (35.3)  
Laterality Left 13 (32.5) 27 (67.5) 0.40
  Right 21 (41.2) 30 (58.8)  
Tumor size ≥ 8 cm 25 (40.3) 37 (59.7) 0.39
  < 8 cm 9 (31.0) 20 (69.0)  
Pathologic fracture at diagnosis Yes 3 (60.0) 2 (40.0) 0.36*
  No 31 (36.0) 55 (64.0)  
Skip lesion Yes 2 (66.7) 1 (33.3) 0.55*
  No 32 (36.4) 56 (63.6)  
Intracapsular extension Yes 13 (65.0) 7 (35.0) 0.004
  No 21 (29.6) 50 (70.4)  
ALP at diagnosis Elevated 26 (46.4) 30 (53.6) 0.02
  Normal 8 (22.9) 27 (77.1)  
LDH at diagnosis Elevated 5 (55.6) 4 (44.4) 0.12*
  Normal 14 (26.4) 39 (73.6)  
Histologic type Osteoblastic/chondroblastic/fibroblastic 19 (29.2) 46 (70.8) 0.02
  Others (mixed and nonconventional type) 9 (60.0) 6 (40.0)  
Limb salvage surgery type Without Pasteurization 28 (36.4) 49 (63.6) 0.64
  With Pasteurization 6 (42.9) 8 (57.1)  
Huvos grade I & II 15 (57.7) 11 (42.3) 0.01
  III & IV 19 (29.2) 46 (70.8)  
Surgical resection Complete 28 (32.9) 57 (67.1) 0.002*
  Incomplete 6 (100.0) 0 (0.0)  
  1. Abbreviation: ALP alkaline phosphatase, LDH lactate dehydrogenase.
  2. *Calculated using Fisher’s extract test.