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Table 3 Incidence of CTC phenotypes according to the co-expression of ALDH1 and TWIST on single CTCs of patients with early and metastatic breast cancer

From: Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer

CTC phenotypes Patients (%) Percentage of CTCs per patient (mean; range) CTCs (%)
  Early Metastatic p value Early Metastatic p value Early Metastatic
ALDH1high / TWISTnuc 15.4 76.0 0.001 6 (0–50) 64 (0–100) 0.000 12.9 61.5
ALDH1high / TWISTcyt/neg 23.1 24.0 1.000 17 (0–100) 11 (0–100) 0.746 25.8 22.0
ALDH1low/neg / TWISTnuc 30.8 12.0 0.330 23 (0–100) 8 (0–100) 0.152 19.4 8.8
ALDH1low/neg / TWISTcyt/neg 61.5 20.0 0.078 54 (0–100) 16 (0–100) 0.026 41.9 7.7
  1. Chi-square test (Continuity Correction) and Mann Whitney test were used. Only patients with detectable CTCs were included; early setting: 13 patients and 31 CTCs; metastatic setting: 25 patients and 91 CTCs.