Immunostaining of DR, histopathology of necroinflammation and fibrosis/cirrhosis. (A, C) Ballooning degeneration (arrowheads), steatosis (thin arrows) and focal necrosis (thick arrows) were shown in the peritumoral parenchyma. (B) Cirrhosis and interface hepatitis were shown. (D) Fibrosis/cirrhosis and portal inflammation were shown. (E) Increased DR was around a nodule in the peritumoral tissue. (F) Decreased DR was around a nodule in the peritumoral tissue. (G) DR and necroinflammation were shown. Ballooning degeneration, steatosis and focal necrosis were nearby DR. Inflammatory cells were around DR in the portal tracts. (H) DR and cirrhosis were shown. DR was at the periphery of a cirrhotic nodule. (A and G 200×; C 400×; B, D, E, F and H 100×).