Table 2 Risk estimation based on the distributions of genotype and allele frequency
microRNA | Model | Genotype | Controls n (%) | HCCs n (%) | AORa(95% CI) | P | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
miR-196a2 | Codominant | TT | 121 (29.8) | 60 (19.1) | 1.00 | 7e-04 | 980.3 | 1003.2 |
| Â | Â | CT | 214 (52.7) | 209 (66.6) | 1.95 (1.36-2.81) | Â | Â | Â |
| Â | Â | CC | 71 (17.5) | 45 (14.3) | 1.28 (0.79-2.08) | Â | Â | Â |
| Â | Dominant | TT | 121 (29.8) | 60 (19.1) | 1.00 | 0.0011 | 982.3 | 1000.7 |
|  |  | CT + CC | 285 (70.2) | 254 (80.9) | 1.79 (1.25-2.54) |  |  |  |
|  | Recessive | TT + CT | 335 (82.5) | 269 (85.7) | 1.00 | 0.26 | 991.8 | 1010.1 |
| Â | Â | CC | 71 (17.5) | 45 (14.3) | 0.79 (0.53-1.19) | Â | Â | Â |
|  | Overdominant | TT + CC | 192 (47.3) | 105 (33.4) | 1.00 | 2e-04 | 979.3 | 997.6 |
| Â | Â | CT | 214 (52.7) | 209 (66.6) | 1.77 (1.31-2.41) | Â | Â | Â |
| Â | Addictive | Â | Â | Â | 1.20 (0.95-1.52) | 0.12 | 990.6 | 1008.9 |
| Â | Allele | T | 457 (56.0) | 329 (52.0) | 1.00 | 0.156 | Â | Â |
| Â | Â | C | 357 (44.0) | 299 (48.0) | 1.16 (0.94-1.43) | Â | Â | Â |
miR-499 | Codominant | TT | 301 (74.1) | 195 (62.1) | 1.00 | 0.0015 | 982.1 | 1005 |
| Â | Â | CT | 101 (24.9) | 117 (37.3) | 1.79 (1.30-2.47) | Â | Â | Â |
| Â | Â | CC | 4 (1) | 2 (0.6) | 0.73 (0.13-4.06) | Â | Â | Â |
| Â | Dominant | TT | 301 (74.1) | 195 (62.1) | 1.00 | 6e-04 | 981.2 | 999.5 |
|  |  | CT + CC | 105 (25.9) | 119 (37.9) | 1.75 (1.27-2.40) |  |  |  |
|  | Recessive | TT + CT | 402 (99.0) | 312 (99.4) | 1.00 | 0.57 | 992.7 | 1011 |
| Â | Â | CC | 4 (1.0) | 2 (0.6) | 0.61 (0.11-3.38) | Â | Â | Â |
|  | Overdominant | TT + CC | 305 (75.1) | 197 (62.7) | 1.00 | 3e-04 | 980.2 | 998.5 |
| Â | Â | CT | 101 (24.9) | 117 (37.3) | 1.80 (1.30-2.48) | Â | Â | Â |
| Â | Addictive | Â | Â | Â | 1.64 (1.21-2.23) | 0.0014 | 982.9 | 1001.2 |
| Â | Allele | T | 704 (86.0) | 507 (81.0) | 1.00 | 0.003 | Â | Â |
| Â | Â | C | 110 (14.0) | 121 (19.0) | 1.53 (1.15-2.03) | Â | Â | Â |
miR-146a | Codominant | CC | 159 (39.2) | 149 (47.5) | 1.00 | 0.017 | 986.8 | 1009.7 |
| Â | Â | CG | 244 (60.1) | 165 (52.5) | 0.71 (0.53-0.96) | Â | Â | Â |
| Â | Â | GG | 3 (0.7) | 0 (0) | 0.00 (0.00-NA) | Â | Â | Â |
| Â | Dominant | CC | 159 (39.2) | 149 (47.5) | 1.00 | 0.02 | 987.6 | 1005.9 |
|  |  | CG + GG | 247 (60.8) | 165 (52.5) | 0.70 (0.52-0.95) |  |  |  |
|  | Recessive | CC + CG | 403 (99.3) | 314 (100) | 1.00 | 0.074 | 989.8 | 1008.2 |
| Â | Â | GG | 3 (0.7) | 0 (0.0) | 0.00 (0.00-NA) | Â | Â | Â |
|  | Overdominant | CC + GG | 162 (39.9) | 149 (47.5) | 1.00 | 0.033 | 988.5 | 1006.8 |
| Â | Â | CG | 244 (60.1) | 165 (52.5) | 0.72 (0.54-0.97) | Â | Â | Â |
| Â | Addictive | Â | Â | Â | 0.69 (0.51-0.93) | 0.013 | 986.9 | 1005.2 |
| Â | Allele | C | 564 (69.0) | 463 (74.0) | 1.00 | 0.065 | Â | Â |
| Â | Â | G | 250 (31.0) | 165 (26.0) | 0.80 (0.64-1.01) | Â | Â | Â |
miR-301b | Codominant | AA | 319 (78.6) | 248 (79.0) | 1.00 | 0.96 | 994.9 | 1017.8 |
| Â | Â | AG | 85 (20.9) | 65 (20.7) | 1.00 (0.69-1.43) | Â | Â | Â |
| Â | Â | GG | 2 (0.5) | 1 (0.3) | 0.70 (0.06-7.78) | Â | Â | Â |
| Â | Dominant | AA | 319 (78.6) | 248 (79.0) | 1.00 | 0.95 | 993 | 1011.3 |
|  |  | AG + GG | 87 (21.4) | 66 (21.0) | 0.99 (0.69-1.42) |  |  |  |
|  | Recessive | AA + AG | 404 (99.5) | 313 (99.7) | 1.00 | 0.77 | 992.9 | 1011.3 |
| Â | Â | GG | 2 (0.5) | 1 (0.3) | 0.70 (0.06-7.78) | Â | Â | Â |
|  | Overdominant | AA + GG | 321 (79.1) | 249 (79.3) | 1.00 | 0.99 | 993 | 1011.3 |
| Â | Â | AG | 85 (20.9) | 65 (20.7) | 1.00 (0.69-1.44) | Â | Â | Â |
| Â | Addictive | Â | Â | Â | 0.98 (0.69-1.40) | 0.92 | 993 | 1011.3 |
| Â | Allele | A | 725 (89.0) | 561 (89.0) | 1.00 | 0.872 | Â | Â |
| Â | Â | G | 89 (11.0) | 67 (11.0) | 0.97 (0.70-1.36) | Â | Â | Â |