Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology

Table 1 Characteristics of the 33 patients and their FFPE samples analyzed (%)

		Total	KIT^L541	KIT^WT
		n = 33	n = 5	n = 22
Patients
Gender	Male	11 (33)
	Female	22 (67)
Median age at diagnosis
[range], years		40 [20–72]	48 [39–57]	39 [20–72]
			Chi-2: p = 0,22
Tumor location	Intra abdo	6 (18)	-	2 (9)
	Abdo wall	3 (9)	2 (40)	4 (18)
	Extra abdo	24 (73)	3 (60)	15 (68)
			Chi-2: p = 0,51
Median tumor size [range], mm		100 [25–220]	70 [60–189]	92 [33–220]
			Chi-2: p = 0,44
Familial Adenomatous Polyposis	Yes	5 (15)
	No	28 (85)
Performans status	0	22 (67)
	1	8 (24)
	2	1 (3)
	Unknown	2 (6)
Median TTP [range], months		24.6 [2.8-42.3]
FFPE samples
Blocks age	1997-1999	11 (33%)
	2000-2005	22 (66%)
Mean DNA quantity [range], ng/μl		782,14 [106,42-1748,86]
Mean A260/280 ratio [range]		1,98 [1,76-2,05]

ISSN: 1471-2407