Figure 4
From: MiR-181b sensitizes glioma cells to teniposide by targeting MDM2
Downregulation of MDM2 promotes cell sensitivity to teniposide. A: The mRNA (p < 0.01) and phosphate protein level of MDM2 were all reduced after transient transfection of siRNAs in U87 cells. B: The IC50 of U87 cells to teniposide dropped from 5.86 ± 0.36 μg/ml to 2.90 ± 0.35 μg/ml upon the knockdown of MDM2.