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Table 2 Correlations between age group and clinicopathological features, including EGFR status

From: Clinicopathological features and EGFR gene mutation status in elderly patients with resected non–small-cell lung cancer

  No. of patients
Characteristics Total ≥80 years <80 years p a
  (n = 388) (n = 29, 7.5%) (n = 359, 92.5%)  
Mean age, yr ± SDb 66.6 ± 10.0 82.6 ± 2.41 65.3 ± 9.29 <0.001
Gender     0.246
Male 228 20 208  
Female 160 9 151  
Histology     0.034
Adenocarcinoma 302 18 284  
others 86 11 75  
Biomarker     
EGFR wild type 203 22 181 0.008
EGFR mutation 185 7 178  
KRAS wild type 355 23 332 0.014
KRAS mutation 33 6 27  
Vascular invasion     
Ly - 314 26 288 0.214
Ly + 74 3 71  
V - 261 18 243 0.535
V + 127 11 116  
p-stage     0.080
I 293 18 275  
II / III 95 11 84  
T-factor     0.506
T1 197 13 184  
T2/3 191 16 175  
Tumor diameter (cm) 3.03 ± 1.43 3.00 ± 1.44 3.40 ± 1.24 0.629
N-factor     0.584
N0 322 23 299  
N1/2 66 6 60  
Operation     0.155
Limited resection (wedge/segmentectomy) 80 3 77  
Standard surgery (lobectomy, pneumonectomy) 308 26 282  
Lymph node resection     <0.001
ND0/1/sampling 109 25 156  
ND2 278 4 203  
Smoking     0.024
Non-smoker 157 6 151  
Smoker 231 23 208  
Pre-existing cardiopulmonary comorbidity 203 21 182 0.024
  1. ap < 0.05 statistically significant.
  2. bSD, standard deviation.
  3. EGFR, epidermal growth factor receptor; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; ND, lymph node dissection.