Table 1 Results from the pre-specified multivariate Cox model
Prognostic factors | Hazard ratio (95.34% CI) | p-value |
|---|---|---|
Treatment: FOLFIRI-aflibercept versus FOLFIRI-placebo | 0.817 [0.713; 0.936] | 0.0032 |
ECOG PS: 1 vs 0 | 1.683 [1.465; 1.935] | < 0.0001 |
ECOG PS: 2 vs 0 | 3.625 [2.395; 5.486] | <0.0001 |
Prior bevacizumab: yes vs no | 1.165 [1.003; 1.353] | 0.0425 |
Age (years): ≥65 vs <65 | 1.179 [1.020; 1.363] | 0.0233 |
Prior hypertension: yes vs no | 0.785 [0.682; 0.904] | 0.0007 |
Number of metastatic organs involved as per IRC: >1 vs (0–1) | 1.446 [1.258; 1.663] | < 0.0001 |