High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Table 2 Correlation between combined expression level of LSD1, HDAC2 and SIRT1 and tumor differentiation

N = 460	3× low	1× high	2× high	3× high	Total
Tumor differentiation
High	31 (23.7%)	9 (8.4%)	21 (15.4%)	10 (11.6%)	71 (15.4%)
Moderate	73 (55.7%)	52 (49.1%)	58 (42.3%)	39 (45.4%)	222 (48.3%)
Low	27 (20.6%)	45 (42.5%)	58 (42.3%)	37 (43.0%)	167 (36.3%)
Total	131	106	137	86	460
Chi-square: p < 0.001

Tumor differentiation, according to tumor grade as assessed by an experienced pathologist, versus the combined expression levels of LSD1, HDAC2 and SIRT1 in 460 breast cancer patients are shown. Patients were divided in four subgroups based on the expression levels of the histone-modifying enzymes: all enzymes below median (3x low), one enzyme above median (1× high), two enzymes above median (2× high) and all three enzymes above median (3x high).

ISSN: 1471-2407