N = 460 | 3Ă— low | 1Ă— high | 2Ă— high | 3Ă— high | Total |
---|
Tumor differentiation | Â |
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High | 31 (23.7%) | 9 (8.4%) | 21 (15.4%) | 10 (11.6%) | 71 (15.4%) |
Moderate | 73 (55.7%) | 52 (49.1%) | 58 (42.3%) | 39 (45.4%) | 222 (48.3%) |
Low | 27 (20.6%) | 45 (42.5%) | 58 (42.3%) | 37 (43.0%) | 167 (36.3%) |
Total | 131 | 106 | 137 | 86 | 460 |
Chi-square: p < 0.001 | Â |
- Tumor differentiation, according to tumor grade as assessed by an experienced pathologist, versus the combined expression levels of LSD1, HDAC2 and SIRT1 in 460 breast cancer patients are shown. Patients were divided in four subgroups based on the expression levels of the histone-modifying enzymes: all enzymes below median (3x low), one enzyme above median (1Ă— high), two enzymes above median (2Ă— high) and all three enzymes above median (3x high).