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Table 3 Family history of gastroesophageal disorders and risk of esophageal and gastric adenocarcinoma

From: Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

History among first degree relatives   EA GCA DGA
Controls Cases OR (95% CI)a P a Cases OR (95% CI)a P a Cases OR (95% CI)a P a
Any ulcer           
 No 1010 108 1.00 (ref)   138 1.00 (ref)   223 1.00 (ref)  
 Yes 279 38 1.49 (0.99-2.25) 0.057 40 1.13 (0.77-1.66) 0.54 59 1.04 (0.74-1.47) 0.80
Gastritis           
 No 1168 134 1.00 (ref)   165 1.00 (ref)   257 1.00 (ref)  
 Yes 112 12 0.97 (0.51-1.87) 0.93 9 0.59 (0.29-1.21) 0.15 24 1.02 (0.62-1.67) 0.95
Hiatal hernia           
 No 1200 130 1.00 (ref)   153 1.00 (ref)   268 1.00 (ref)  
 Yes 80 16 2.04 (1.12-3.71) 0.020 22 2.31 (1.37-3.91) 0.002 10 0.90 (0.44-1.84) 0.77
Barrett’s esophagus           
 No 1272 141 1.00 (ref)   169 1.00 (ref)   259 1.00 (ref)  
 Yes 5 2 - - 0 - - 0 - -
  1. Abbreviations: EA, esophageal adenocarcinoma; GCA, gastric cardiac adenocarcinoma; DGA, distal gastric adenocarcinoma; OR, odds ratio; CI, confidence interval.
  2. aResults were estimated from multivariate polytomous logistic regression, with adjustment for age, sex, race, education, birth place, cigarette smoking status, body mass index and history of diabetes. History of any ulcer, gastritis, hiatal hernia, and Barrett’s esophagus among first degree relatives was unknown for 28, 42, 44, and 75 participants respectively.