Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

Table 3 Family history of gastroesophageal disorders and risk of esophageal and gastric adenocarcinoma

History among first degree relatives		EA			GCA			DGA
History among first degree relatives	Controls	Cases	OR (95% CI)^a	P ^a	Cases	OR (95% CI)^a	P ^a	Cases	OR (95% CI)^a	P ^a
Any ulcer
No	1010	108	1.00 (ref)		138	1.00 (ref)		223	1.00 (ref)
Yes	279	38	1.49 (0.99-2.25)	0.057	40	1.13 (0.77-1.66)	0.54	59	1.04 (0.74-1.47)	0.80
Gastritis
No	1168	134	1.00 (ref)		165	1.00 (ref)		257	1.00 (ref)
Yes	112	12	0.97 (0.51-1.87)	0.93	9	0.59 (0.29-1.21)	0.15	24	1.02 (0.62-1.67)	0.95
Hiatal hernia
No	1200	130	1.00 (ref)		153	1.00 (ref)		268	1.00 (ref)
Yes	80	16	2.04 (1.12-3.71)	0.020	22	2.31 (1.37-3.91)	0.002	10	0.90 (0.44-1.84)	0.77
Barrett’s esophagus
No	1272	141	1.00 (ref)		169	1.00 (ref)		259	1.00 (ref)
Yes	5	2	-	-	0	-	-	0	-	-

Abbreviations: EA, esophageal adenocarcinoma; GCA, gastric cardiac adenocarcinoma; DGA, distal gastric adenocarcinoma; OR, odds ratio; CI, confidence interval.
^aResults were estimated from multivariate polytomous logistic regression, with adjustment for age, sex, race, education, birth place, cigarette smoking status, body mass index and history of diabetes. History of any ulcer, gastritis, hiatal hernia, and Barrett’s esophagus among first degree relatives was unknown for 28, 42, 44, and 75 participants respectively.

ISSN: 1471-2407