History of cancer among first degree relatives | EA | GCA | DGA | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Controls | Cases | OR (95% CI)a | P a | Cases | OR (95% CI)a | P a | Cases | OR (95% CI)a | P a | |
Any cancer | ||||||||||
No | 668 | 68 | 1.00 (ref) | 90 | 1.00 (ref) | 160 | 1.00 (ref) | |||
Yes | 629 | 78 | 1.02 (0.68-1.54) | 0.92 | 91 | 1.04 (0.71-1.53) | 0.83 | 122 | 0.83 (0.60-1.15) | 0.27 |
Late-onset | 481 | 58 | 0.96 (0.62-1.49) | 0.85 | 63 | 0.96 (0.63-1.46) | 0.84 | 89 | 0.81 (0.56-1.16) | 0.25 |
Early-onset | 148 | 20 | 1.24 (0.66-2.35) | 0.50 | 28 | 1.33 (0.74-2.38) | 0.34 | 33 | 0.90 (0.54-1.48) | 0.67 |
Gastrointestinal cancer | ||||||||||
Any gastrointestinal cancerb | ||||||||||
No | 1101 | 125 | 1.00 (ref) | 148 | 1.00 (ref) | 226 | 1.00 (ref) | |||
Yes | 196 | 21 | 0.87 (0.48-1.59) | 0.66 | 33 | 1.19 (0.71-1.97) | 0.51 | 56 | 1.45 (0.95-2.23) | 0.087 |
Late-onset | 153 | 16 | 0.85 (0.44-1.65) | 0.63 | 26 | 1.23 (0.70-2.14) | 0.47 | 40 | 1.31 (0.80-2.16) | 0.28 |
Early-onset | 43 | 5 | 0.98 (0.29-3.33) | 0.97 | 7 | 1.04 (0.36-3.02) | 0.95 | 16 | 1.84 (0.90-3.78) | 0.095 |
Esophageal cancer | ||||||||||
No | 1290 | 145 | 1.00 (ref) | 176 | 1.00 (ref) | 280 | 1.00 (ref) | |||
Yes | 7 | 1 | - | - | 5 | 5.18 (1.23-21.79) | 0.025 | 2 | - | - |
Gastric cancer | ||||||||||
No | 1241 | 141 | 1.00 (ref) | 171 | 1.00 (ref) | 260 | 1.00 (ref) | |||
Yes | 56 | 5 | 0.92 (0.32-2.65) | 0.87 | 10 | 1.57 (0.72-3.45) | 0.26 | 22 | 2.15 (1.18-3.91) | 0.012 |
Colorectal cancer | ||||||||||
No | 1222 | 138 | 1.00 (ref) | 171 | 1.00 (ref) | 260 | 1.00 (ref) | |||
Yes | 75 | 8 | 0.94 (0.39-2.27) | 0.89 | 10 | 0.70 (0.27-1.79) | 0.46 | 22 | 1.21 (0.61-2.39) | 0.59 |
Liver cancer | ||||||||||
No | 1267 | 139 | 1.00 (ref) | 179 | 1.00 (ref) | 276 | 1.00 (ref) | |||
Yes | 30 | 7 | 1.94 (0.64-5.83) | 0.24 | 2 | - | - | 6 | 0.51 (0.13-2.01) | 0.34 |
Pancreatic cancer | ||||||||||
No | 1275 | 145 | 1.00 (ref) | 176 | 1.00 (ref) | 276 | 1.00 (ref) | |||
Yes | 22 | 1 | - | - | 5 | 1.55 (0.44-5.43) | 0.49 | 6 | 2.17 (0.72-6.51) | 0.17 |
Non-gastrointestinal cancer | ||||||||||
Lung cancer | ||||||||||
No | 1202 | 132 | 1.00 (ref) | 164 | 1.00 (ref) | 267 | 1.00 (ref) | |||
Yes | 95 | 14 | 1.03 (0.48-2.24) | 0.93 | 17 | 0.92 (0.43-1.98) | 0.84 | 15 | 1.05 (0.52-2.11) | 0.90 |
Upper respiratory organ cancer | ||||||||||
No | 1172 | 128 | 1.00 (ref) | 157 | 1.00 (ref) | 260 | 1.00 (ref) | |||
Yes | 125 | 18 | 0.98 (0.50-1.93) | 0.96 | 24 | 1.22 (0.67-2.20) | 0.51 | 22 | 1.02 (0.57-1.85) | 0.94 |
Skin/bone/connective tissue cancer | ||||||||||
No | 1225 | 141 | 1.00 (ref) | 174 | 1.00 (ref) | 272 | 1.00 (ref) | |||
Yes | 72 | 5 | 0.61 (0.21-1.74) | 0.35 | 7 | 0.44 (0.14-1.46) | 0.18 | 10 | 1.06 (0.40-2.79) | 0.90 |
Lymphatic/hematopoietic cancer | ||||||||||
No | 1256 | 141 | 1.00 (ref) | 179 | 1.00 (ref) | 272 | 1.00 (ref) | |||
Yes | 41 | 5 | 1.49 (0.56-3.96) | 0.43 | 2 | - | - | 10 | 0.90 (0.32-2.55) | 0.84 |
Prostate cancer | ||||||||||
No | 1224 | 130 | 1.00 (ref) | 170 | 1.00 (ref) | 272 | 1.00 (ref) | |||
Yes | 73 | 16 | 2.84 (1.50-5.36) | 0.001 | 11 | 1.45 (0.70-3.01) | 0.32 | 10 | 0.44 (0.17-1.16) | 0.10 |
Breast cancer | ||||||||||
No | 1168 | 137 | 1.00 (ref) | 167 | 1.00 (ref) | 258 | 1.00 (ref) | |||
Yes | 129 | 9 | 0.60 (0.28-1.28) | 0.19 | 14 | 0.68 (0.33-1.40) | 0.30 | 24 | 0.78 (0.42-1.45) | 0.44 |
Female reproductive organ cancer | ||||||||||
No | 1228 | 132 | 1.00 (ref) | 167 | 1.00 (ref) | 263 | 1.00 (ref) | |||
Yes | 67 | 14 | 1.59 (0.72-3.51) | 0.25 | 13 | 1.56 (0.74-3.27) | 0.24 | 17 | 1.02 (0.52-2.02) | 0.94 |
Unknown primary site | ||||||||||
No | 1234 | 139 | 1.00 (ref) | 176 | 1.00 (ref) | 270 | 1.00 (ref) | |||
Yes | 63 | 7 | 0.76 (0.29-1.99) | 0.58 | 5 | 0.54 (0.19-1.54) | 0.25 | 12 | 0.80 (0.38-1.66) | 0.55 |