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Figure 3 | BMC Cancer

Figure 3

From: Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells

Figure 3

c-Myc suppression by TGS reduced cell survival. (A) HepG2 cells were transfected with various AFP promoter/enhancer driven test/control shRNAs in different doses and percent cell survival was evaluated by MTT assay on the 6th day. HepG2 cells showed decrease in cell survival with the increasing dose of the constructs and this decrease in cell survival was dependent upon the strength of each construct when compared to its control (p < 0.05). (B) In untransformed Chang Liver cell line, decrease in cell survival was observed only by CMVPr – myc (p = 0.019).

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