Figure 4
CDK11 p58 inhibits ITGB3 promoter activity in MCF-7 and ZR-75-30 cells. (A and B) CDK11p58 inhibits ITGB3 promoter activity in a kinase-dependent manner. Dual luciferase assays were performed in ZR-75-30 and MCF-7 cells as described in Methods. P < 0.05 vs. controls (n = 3 experiments). (C) 293 T cells were transfected with the indicated plasmids, and luciferase assays were performed 48 h later. (D) MDA-MB-231 cells were transfected with the indicated plasmids and luciferase assays were performed 48 h later.