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Table 2 Accuracy of HPV test, cytology and the combination of both tests for CIN2+ prediction

From: Protecting the underscreened women in developed countries: the value of HPV test

 

HPV

CYTOLOGY

HPV + CYTOLOGY

SENSITIVITY (95% CI)

Uncorrecteda

94.4 (92.8-96.1)

44.4 (39.2-49.7)

94.4 (92.8-96.1)

 

Correctedb

90.5 (88.8-92.2)

38.2 (33.9-42.6)

90.5 (88.8-92.2)

SPECIFICITY (95% CI)

Uncorrecteda

88.8 (86.4-91.2)

96.4 (95.1-97.7)

87.2 (84.6-89.7)

 

Correctedb

93.0 (91.5-94.5)

97.8 (97.0-98.7)

91.9 (90.3-93.5)

PPV (95% CI)

Uncorrecteda

16.8 (10.4-23.3)

22.9 (16.6-29.1)

15.0 (21.6-8.5)

 

Correctedb

16.1 (11.0-21.1)

20.9 (15.9-25.8)

14.2 (9.1-19.3)

NPV (95% CI)

Uncorrecteda

99.8 (99.6-100.1)

98.6 (97.8-99.5)

99.8 (99.6-100)

 

Correctedb

99.8 (99.6-100.1)

99.1 (98.5-99.6)

99.8 (99.6-100)

  1. aEstimates based only on data from women who were screened.
  2. bEstimates corrected for bias due to loss of follow-up.
  3. CIN2+: cervical intraepithelial neoplasia grade 2 or worse, hrHPV: HPV testing for high-risk types, PPV: positive predicted value, NPV: negative predicted value, 95% CI: 95% Confidence Interval.
  4. HPV detection was performed with Hybrid Capture 2 test (HC2; Qiagen, Gaithersburg, MD, USA).