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Table 2 Accuracy of HPV test, cytology and the combination of both tests for CIN2+ prediction

From: Protecting the underscreened women in developed countries: the value of HPV test

  HPV CYTOLOGY HPV + CYTOLOGY
SENSITIVITY (95% CI) Uncorrecteda 94.4 (92.8-96.1) 44.4 (39.2-49.7) 94.4 (92.8-96.1)
  Correctedb 90.5 (88.8-92.2) 38.2 (33.9-42.6) 90.5 (88.8-92.2)
SPECIFICITY (95% CI) Uncorrecteda 88.8 (86.4-91.2) 96.4 (95.1-97.7) 87.2 (84.6-89.7)
  Correctedb 93.0 (91.5-94.5) 97.8 (97.0-98.7) 91.9 (90.3-93.5)
PPV (95% CI) Uncorrecteda 16.8 (10.4-23.3) 22.9 (16.6-29.1) 15.0 (21.6-8.5)
  Correctedb 16.1 (11.0-21.1) 20.9 (15.9-25.8) 14.2 (9.1-19.3)
NPV (95% CI) Uncorrecteda 99.8 (99.6-100.1) 98.6 (97.8-99.5) 99.8 (99.6-100)
  Correctedb 99.8 (99.6-100.1) 99.1 (98.5-99.6) 99.8 (99.6-100)
  1. aEstimates based only on data from women who were screened.
  2. bEstimates corrected for bias due to loss of follow-up.
  3. CIN2+: cervical intraepithelial neoplasia grade 2 or worse, hrHPV: HPV testing for high-risk types, PPV: positive predicted value, NPV: negative predicted value, 95% CI: 95% Confidence Interval.
  4. HPV detection was performed with Hybrid Capture 2 test (HC2; Qiagen, Gaithersburg, MD, USA).
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