Skip to main content

Table 1 Cytotoxicities of several drugs against KB and CDDP-resistant cell line, KB/CDDP(T)

From: 3'-Ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

  ECyd CDDP CBDCA ADM SN-38
Cell line IC50 Fold IC50 Fold IC50 Fold IC50 Fold IC50 Fold
μmol/L μmol/L μmol/L μmol/L μmol/L
KB 0.022 1.0 0.82 8.4 28.40 7.5 0.022 3.8 0.002 35
KB/CDDP(T) 0.022 6.92 214.13 0.084 0.070
  1. Cells were exposed to each drug for 72 hr. Data are shown as the mean (n = 4).