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Figure 3 | BMC Cancer

Figure 3

From: 3'-Ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

Figure 3

Simultaneous exposure to ECyd and CDDP causes synergistic cell growth inhibition of cells with higher MVP expression levels. The effect of 24 hours of simultaneous exposure to ECyd and CDDP was analyzed in parental KB cells (A) and KB/CDDP(T) (B) cells. The combined effect of ECyd with CDDP was analyzed using an isobologram analysis according to the method described by Steel and Peckham. Data are shown as the mean (n = 4). C) The basal expression level of MVP protein in SHIN-3 and HRA cells was analyzed using immunoblot analysis. Equal loading was confirmed by the detection of β-actin. D) The combined effect of 24 hours of simultaneous exposure to ECyd and CDDP was analyzed in SHIN-3 (D) and HRA (E) cells. The combined effect of ECyd with CDDP was analyzed using bliss independent combination analysis. Data are shown as the mean (n = 4).

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BMC Cancer

ISSN: 1471-2407

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