Figure 1
From: Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles
Association of melanoma cell ganglioside profile with patients’ survival. (A) Hierarchical clustering analysis of melanoma cell lines on the basis of ganglioside profiles. Dotted line represents the level of significant dissimilarity. (B) HPTLC separation of gangliosides and (C) of neutral sphingolipids of three representative melanoma cell lines (L6, L34, L4) belonging to clusters 1, 2, and 3, in comparison to adult and neonatal melanocytes. (D) Kaplan-Meier survival analysis of patients according to the three clusters identified. Survival was evaluated as time from first diagnosis.