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Table 1 Correlation between lenvatinib treatment-dependent changes in plasma biomarkers and AUC

From: Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib

Plasma Biomarker n Correlation With AUC0-tau
r P Value
IL-6 19 -0.100 .683
IL-8 19 -0.202 .407
IL-10 19 0.061 .802
VEGF 19 0.496 .030
PDGF-BB 19 -0.161 .509
HGF 25 0.263 .203
SCF 25 -0.210 .313
SDF1α 25 0.806 < .0001
sVEGFR1 25 -0.378 .062
sVEGFR2 25 -0.916 < .0001
  1. The concentrations of plasma proteins were measured at baseline and at day 8 of lenvatinib treatment, and the percentage change from baseline was analyzed in correlation with AUC0-tau. Spearman’s correlation coefficient (r) and P value (p) for each analysis is listed.