Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes – an immunohistochemical study

Table 1 Ratio of macrophage marker expression depending on the T-status, N-status, L-status, Pn-status and grading (cell count in the sinus and interfollicular zone (IFZ) of tumor free lymph nodes)

Ratio		CD11c/CD68 LN sinus		CD163/CD68 LN sinus		MRC1/CD68 LN sinus		CD163/CD11c LN sinus		MRC1/CD11c LN sinus		MRC1/CD68 LN IFZ		MRC1/CD11c LN IFZ
		Median	SD	Median	SD	Median	SD	Median	SD	Median	SD	Median	SD	Median	SD
*T-status*	n
T1	17	0.33	0.23	1.09	0.63	4.03	1.72	3.81	2.39	10.07	11.57	0.33	0.19	0.36	0.21
T2	19	0.39	0.36	0.99	0.38	3.36	1.55	3.25	2.81	8.76	8.56	0.6	0.29	0.51	0.4
p-value		0.455		0.464		0.384		0.608		0.328		0.027		0.041
*N-status*	n
N0	19	0.33	0.25	1.08	0.58	3.39	1.92	3.66	2.23	12.46	8.60	0.32	0.24	0.36	0.39
N+	17	0.36	0.36	1.02	0.43	3.65	1.25	3.11	3.00	7.39	11.78	0.60	0.27	0.49	0.29
p-value		0.902		0.963		0.458		0.725		0.958		0.073		0.922
*L-status*	n
L0	26	0.44	0.32	0.99	0.60	3.36	1.67	2.78	1.6	7.19	5.24	0.45	0.25	0.49	0.36
L1	10	0.2	0.14	1.09	0.17	3.52	0.93	5.01	3.35	17.73	13.36	0.35	0.30	0.33	0.28
p-value		0.015		0.747		0.813		0.001		0.001		0.46		0.24
*Pn-status*	n
Pn0	23	0.44	0.33	0.98	0.49	3.22	1.72	2.78	1.58	9.24	5.35	0.44	0.24	0.50	0.37
Pn1	10	0.23	0.14	1.11	0.13	3.66	0.80	5.01	3.35	17.73	13.32	0.37	0.33	0.40	0.28
p-value		0.032		0.717		0.951		0.001		0.002		0.981		0.278
*Grading*	n
G1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
G2	28	0.36	0.31	1.02	0.55	3.39	1.59	2.99	1.96	9.24	8.80	0.42	0.27	0.38	0.36
G3	8	0.26	0.25	1.11	0.36	3.84	1.91	5.39	3.65	17.73	12.39	0.37	0.27	0.46	0.33
p-value		0.225		0.779		0.696		0.048		0.090		0.674		0.787

Table 1 shows the ratio of macrophage marker expression in the sinus and the interfollicular zone (IFZ) of tumor free lymph nodes in cases with different pathohistologic classifications (T1 and T2, N0 and N+, L0 and L1, Pn0 and Pn1, G1 – G3). Values represent the median, standard deviation (SD) and p-value (ANOVA).

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