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Table 1 Clinicopathological data with ICC- and qPCR-status

From: Comparison of molecular and immunocytochemical methods for detection of disseminated tumor cells in bone marrow from early breast cancer patients

  All patients (n = 267) ICC qPCR
  Number (%) Pos Neg p-value Pos Neg p-value
Age (years)      0.14    0.74
  <55 220 (82.4) 21 199   91 129  
  55-70 43 (16.1) 1 42   19 24  
Unknown 4 (1.5)       
pT-status      0.524    0.89
  pT1a 5 (1.9) 2 3   1 4  
  pT1b 14 (5.2) 0 14   6 8  
  pT1c 115 (43.1) 7 108   52 63  
  pT2 113 (42.3) 10 103   44 69  
  pT3 14 (5.2) 3 11   7 7  
Unknown 6 (2.2)       
pN-status      0.14    0.88
  pN0 109 (40.8) 7 102   44 65  
  pN1 118 (44.2) 10 108   52 66  
  pN2 27 (10.1) 4 23   10 17  
  pN3 6 (2.2) 1 5   2 4  
Unknown 7 (2.6)       
Histologic grade      0.80    0.76
  Grade I 18 (6.7) 0 18   7 11  
  Grade II 151 (56.6) 16 135   63 88  
  Grade III 90 (34.2) 6 84   38 52  
  Unclassified 4 (1.5) 0 4   2 2  
Unknown 4 (1.5)       
ER-status      1.00    0.39
  Positive 195 (73.0) 16 179   78 117  
  Negative 67 (25.1) 5 62   31 36  
Unknown 5 (1.9)       
PgR-status      1.00    0.50
  Positive 177 (66.3) 14 163   71 106  
  Negative 84 (31.5) 7 77   38 46  
Unknown 6 (2.2)       
HER2-status      1.00    0.59
  Positive 37 (13.9) 2 35   17 20  
  Negative 204 (76.4) 16 188   83 121  
Unknown 26 (9.7)       
  1. The ICC and RT-qPCR statuses were defined as positive if either BM1 or BM2 was positive. For 238 patients, either BM1 or BM2 was available; whereas, both BM1 and BM2 were available for 29 patients. BM3 and BM4 results were excluded from this analysis because they were only analyzed if ICC BM2 was positive. Four of the 271 patients had only BM3 or BM4 available and were excluded from the analysis in this table.
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