From: Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis
Dose (once-daily)
Patients (n)
Dose (twice-daily)
50Â mg
1
150 mg × 2
4
100Â mg
150 mg + 200 mg
200Â mg
200 mg × 2
250Â mg
250 mg × 2
7
300Â mg
2
–
450Â mg