Table 2 Validation of relative bias of five-year extrapolation based on actual 10-year survival using Kaplan-Meier (K-M) estimates as the gold standard
Stage | Cohort size | Mean age at diagnosis (SD)* | Censored rate (%) | 10-year survival based on K-M estimate in years (SE)† | Extrapolation based on the first five-year follow up in years (SE)† | Relative bias (%) |
|---|---|---|---|---|---|---|
1 | 3,823 | 52.49 (13.20) | 92.68 | 8.60 (0.05) | 8.47 (0.02) | −1.57 |
2 | 1,791 | 60.39 (13.99) | 80.07 | 6.76 (0.10) | 6.69 (0.05) | −1.05 |
3 | 680 | 61.65 (14.91) | 58.38 | 4.69 (0.15) | 4.53 (0.08) | −3.57 |
4 | 373 | 60.40 (14.69) | 39.68 | 2.71 (0.15) | 2.45 (0.10) | −9.54 |