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Table 1 Description of the common chemotherapy regimens used in the series

From: An effective and well-tolerated strategy in recurrent and/or metastatic head and neck cancer: successive lines of active chemotherapeutic agents

Platinum based regimens (name and dose) Platinum free regimens (name and dose)
Cisplatin (100 mg/m2/3 weeks) + 5-FU (1000 mg/m2/d, 5 days/3 weeks) Paclitaxel (60 to 80 mg/m2/week) + Cetuximab (400 mg/m2 then 250 mg/m2/week)
Cisplatin (75 mg/m2/3 weeks) + Docetaxel (75 mg/m2/3 weeks) Paclitaxel (80 mg/m2/week)
Cisplatin (75 mg/m2/3 weeks) + Docetaxel (75 mg/m2/3 weeks) + Cetuximab (400 mg/m2 then 250 mg/m2/week) Methotrexate (40 mg/m2/week)
Cisplatin (75 mg/m2/3 weeks) + Docetaxel (75 mg/m2/3 weeks) + 5-FU (750 mg/m2/d, 5 days/3 weeks) Capecitabine (1,000 mg/m2 BID for 14 days/21 days)
Cisplatin (100 mg/m2/3 weeks) + 5-FU (1000 mg/m2/d, 4 days/3 weeks) + Cetuximab (400 mg/m2 then 250 mg/m2/week)  
Carboplatin (AUC5/3 weeks) + 5-FU (1000 mg/m2/d, 4 days/3 weeks) + Cetuximab (400 mg/m2 then 250 mg/m2/week)  
Carboplatin (AUC5/3 weeks) + Paclitaxel (80 mg/m2/week)  
Carboplatin (AUC5/3 weeks)  
  1. 5-FU = 5-Fluorouracil.
  2. AUC = Area Under the Curve.