Table 1 AHR-active pharmaceuticals as AHR agonists in MDA-MB-231 breast cancer cells
From: The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
AHR agonist | mRNA | Protein | ||
|---|---|---|---|---|
| Â | CYP1A1 | CYP1B1 | CYP1A1 | AHR |
40-Hydroxytamoxifen | >50 | >50 | ni | decreased |
Sulindac | <50 | >50 | ni | decreased |
Flutamide | <50 | >50 | ni | unchanged |
Tranilast | <50 | <50 | ind | decreased |
Leflunomide | <50 | >50 | ind | decreased |
Nimodipine | <50 | >50 | ind | decreased |
Mexiletine | <50 | >50 | ind | decreased |
Omeprazole | <50 | <50 | ind | decreased |