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Table 2 Diagnostic values, including sensitivity, specificity, positive predictive value and negative predictive value, combining assay seromarkers

From: Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma

Combinations Sensitivity(%) Specificity(%) PPV(%) NPV(%)
YKL-40 72.70 84.13 84.50 72.11
CEA 8.00 96.80 75.00 46.72
CYFRA21-1 40.00 92.06 85.71 56.31
YKL-40 or CEA 74.00 83.20 84.09 72.73
YKL-40 or CYFRA21-1 82.00 77.78 81.46 78.40
CEA or CYFRA21-1 44.00 89.60 69.47 57.14
YKL-40 or CEA or CYFRA21-1 83.33 76.80 81.17 79.34
  1. Cut-off values: 58.0 ng/ml for YKL-40; 5.0 ng/ml for CEA; 3.3 ng/ml for CYFRA21-1; 1.5 ng/ml for SCCA.