Table 2 Indirect comparisons of available treatments for advanced pancreatic cancer

FOLFIRINOX vs.

Gemcitabine

0.57 (0.45-0.72)*

4.22 (2.12-6.92)*

0.59 (0.37-0.47)*

3.73 (0.98-6.48)*

Gemcitabine + NAB-P

0.79 (0.59-1.05)

1.46 (-0.27-3.81)

0.68 (0.51-0.91)*

1.54 (0.32-3.16)*

Gemcitabine + Oxaliplatin

0.66 (0.50-0.88)*

2.83 (0.76-5.59)*

0.60 (0.43-0.85)*

2.17 (0.58-4.43)*

Gemcitabine + Capecitabine

0.70 (0.53-0.92)*

2.42 (0.48-5.0)

0.58 (0.45-0.74)*

2.40 (1.14-4.01)*

Gemcitabine + Cisplatin

0.58 (0.43-0.78)*

4.06 (1.62-7.3)

0.46 (0.34-0.62)*

3.94 (2.03-6.53)*

Gemcitabine +5FU

0.70 (0.49-0.97)*

2.45 (0.17-5.63)*

0.61 (0.44-0.84)*

2.11 (0.63-4.14)*

Gemcitabine + 5FU/FA

0.55 (0.40-0.74)*

4.62 (1.93-8.28)*

n/a

n/a

Gemcitabine + pemetrexed

0.58 (0.43-0.74)*

4.03 (1.51-7.41)*

n/a

n/a

Gemcitabine + irinotecan

0.55 (0.39-0.76)*

4.62 (1.76-8.54)*

n/a

n/a

PEFG

0.88 (0.54-1.43)

0.80 (-1.66-4.76)

0.92 (0.57-1.48)

0.28 (-1.07-2.47)

Gemcitabine + exatecan

0.58 (0.43-0.79)*

4.03 (1.44-7.53)*

n/a

n/a

Gemcitabine + erlotinib

0.70 (0.51-0.94)*

3.94 (1.47-3.94)*

0.61 (0.45-0.82)*

2.11 (0.72-3.96)*

Gemcitabine + erlotinib + bevacizumab

0.78 (0.55-1.11)

1.57 (-0.55-4.61)

0.63 (0.45-0.88)*

1.95 (0.44-4.08)*

Gemcitabine + axinitib

0.56 (0.40-0.80)*

4.36 (1.40-8.54)*

0.47 (0.33-0.66)*

3.76 (1.70-6.68)*

Gemcitabine + tipifarnib

0.59 (0.44-0.79)*

3.94 (1.47-7.27)*

0.64 (0.48-0.86)*

1.82 (0.54-3.54)*

Gemcitabine + marismastat

0.58 (0.40-0.83)*

4.13 (1.18-8.38)*

0.49 (0.35-0.70)*

3.37 (1.41-6.15)*

Gemcitabine + Sorafenib

0.45 (0.28-0.73)*

6.89 (2.11-14.6)*

0.45 (0.28-0.72)*

4.00 (1.30-8.32)*

Gemcitabine + Cetuximab

0.54 (0.40-0.71)*

4.82 (2.24-8.25)*

0.44 (0.33-0.58)*

4.21 (2.41-6.56)*

Capecitabine + erlotinib

0.68 (0.46-1.00)

1.08 (0.67-6.30)

0.60 (0.88-1.30)

0.76 (0.43-2.20)