Figure 3
A model for the genetic predispositions in familial breast cancer. The known predisposition in BRCA1 has the highest sharing frequency in the disease population, other known predispositions decrease their frequencies towards extreme rarity in the disease populations, and the family-specific predispositions are enriched in many disease families without known predispositions. The biggest circle represents the entire genetic predispositions in familial breast cancer. The open circles represent the shared, known predispositions, and the black circles represent the family-specific predispositions.