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Table 1 Patient characteristics (n = 44)

From: Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival

Median age, years (range)

71 (49–86)

Gender Male/female

19/25

Performance status

 

0

24 (54.5)

1

14 (31.8)

2

4 (9.1)

≥3

2 (4.5)

Type of M protein n (%)

 

IgG

22 (50.0)

IgA

10 (22.7)

IgD

1 (2.3)

BJP

10 (22.7)

No secreted

1 (2.3)

Durie-Salmon stage n (%)

 

I

4 (9.1)

II

6 (13.6)

III

34 (77.3)

ISS stage n (%)

 

1

10 (22.7)

2

11 (25.0)

3

23 (52.3)

No. genetic abnormalities of 13q deletion n (%)

 

Yes

6 (13.6)

No

38 (86.4)

No. of stem cell transplantation n (%)

 

Yes

15 (34.1)

No

29 (65.9)

No. of prior treatment regimens* n (%) 09 (20.5)

 

1

16 (36.4)

2

7 (15.9)

≥3

12 (27.3)

Type of prior treatment regimens n (%)

 

VAD

22 (25.9)

MP

19 (22.4)

HDD

10 (11.8)

Thalidomide

9 (10.6)

Stem cell transplantation

5 (5.9)

CP

5 (5.9)

ROAD

4 (4.7)

Cyclophosphamide alone

3 (3.5)

DEX pulse

2 (2.4)

MD

2 (2.4)

INF α-MP

2 (2.4)

CAD

1 (1.2)

RD

1 (1.2)

  1. CP: cyclophosphamide, prednisolone; CAD: cyclophosphamide, adriamycin, dexamethasone; DEX pulse: dexamethasone pulse therapy; MD: melphalan, dexamethasone; MP: melphalan, prednisolone; HDD: high dose dexamethasone; INF α: Interferon Alpha, RD: lenalidomide, dexamethasone; ROAD: MCNU, vincristine, melphalan, dexamethasone; VAD: vincristine, adriamycin, dexamethasone.
  2. *A regimen was defined as a single drug or combination therapy. Front-line therapy could be composed of more than one regimen.