Figure 1

Expression of integrin α3 and COX2 in human IDC (Pantomics TMA). (A) Images show representative scoring intensities following immunostaining of adjacent regions from the same tumor with the indicated antibodies (range of 0-3; see Methods). Tissues were also stained with DAB as chromogen, and counter-stained with hematoxylin. The pre-immune serum (first column) was used to determine background staining for each set. Scale bar, 25 μM. (B) Table depicts co-distribution of like scores for α3 and COX2. Blue shading highlights a positive correlation for expression of α3 and COX2 among the 59 IDC samples. Spearman’s rank correlation coefficient (r_s = 0.49; p < 0.001) indicates a significant correlation between α3 and COX2 expression (see Table 2).