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Table 1 Clinicopathological variables in 92 consecutive pancreatoduodenectomies for pancreatic cancer stratified by COX-2 status

From: COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis

Characteristic n(%) COX2-neg. n(%) COX2-pos. n(%) pa
COX-2     
Positive 65 (71%)    
Negative 27 (29%)    
Tumour size     
≤ 20 mm 15 (16%) 3 (20%) 12 (80%)  
> 20 mm 77 (84%) 24 (31%) 53 (69%) 0.54b
Lymph node metastasis     
N0, n (%) 25 (27%) 5 (20%) 20 (80%)  
N1, n (%) 67 (73%) 22 (33%) 45 (67%) 0.229
Lymph node ratio (LNR)c     
≤ 0.2 54 (59%) 13 (24%) 41 (76%)  
> 0.2 37 (41%) 13 (36%) 24 (65%) 0.251
Vascular invasion     
No, n (%) 30 (33%) 12 (40%) 18(60%)  
Yes, n (%) 62 (67%) 15 (24%) 47 (76%) 0.119
Perineural infiltration     
No, n (%) 15 (16%) 3 (20%) 12 (80%)  
Yes, n (%) 77 (84%) 24 (31%) 53 (69%) 0.54b
T classification     
T1 3 (3%) 1 (33%) 2 (67%)  
T2 6 (7%) 1 (17%) 5 (83%)  
T3 83 (90%) 25 (30%) 58 (70%) 0.851b
R1 resection status, n (%)     
R0, n (%) 40 (44%) 10 (25%) 30 (75%)  
R1, n (%) 52 (56%) 17 (33%) 35 (67%) 0.422
Degree of differentiation     
Grade I, II 53 (58%) 9 (17%) 44 (83%)  
Grade III, IV 39 (42%) 18 (46%) 21 (54%) 0.002
Type of differentiation     
Pancreaticobiliary, n (%) 84 (91%) 27 (32%) 57 (68%)  
Intestinal, n (%) 8 (9%) 0 (0%) 8 (100%) 0.099b
  1. PC, pancreatic adenocarcinoma.
  2. aChi-square test, when not otherwise specified.
  3. bFisher’s Exact Test.
  4. cLNR assessment of 91 patients since in one specimen no lymph nodes were retrieved.