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Table 2 Single cell mutation analysis of DTCs or primary or metastatic tumor cells

From: Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Patient ID Sample ID Sample type Number DTCs analyzed/total DTCs collected* Number TCs analyzed/total TCs collected* Number DTCs or TCs with PIK3CAexon 9 mutation Number DTCs or TCs with PIK3CAexon 20 mutation
12 12-11 (T) L2 bone metastasis (spine) - 8/10 8 0
12 12-12 (T) Bone marrow 24/75 - 24 0
13 13-1 (T) Primary tumor - 5/10 0 0
14 14-1 (T) Primary tumor (core bx) - 5/10 1 0
15 15-1 (T) LN metastasis - 5/10 3 0
16 16-1 (T) Primary tumor - 5/10 0 0
17 17-1 (T) Primary tumor - 5/10 0 0
TOTALS
6 patients 7 samples - 24/75 33/60 36 0
  1. DTCs disseminated tumor cells from bone marrow, TCs tumor cells from primary or metastatic tumors;
  2. LN lymph node, L2 second lumbar vertebra, Bx biopsy, ND not determined.
  3. *DTCs or TCs not analyzed for mutations were used for immunostaining or other molecular assays.