Skip to main content

Table 1 Single cell mutation analysis of CTCs

From: Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Patient ID

Sample ID

Sample type

Number CTCs analyzed/total CTCs collected*

Number CTCs with PIK3CAexon 9 mutation

Number CTCs with PIK3CAexon 20 mutation

1

1-1

Blood

3/13

0

0

1

1-2

Blood

3/9

0

0

1

1-3

Blood

4/9

0

0

2

2-1

Blood

3/20

0

0

2

2-2

Blood

2/6

0

0

2

2-3

Blood

5/50

0

0

3

3-1

Blood

3/14

0

0

4

4-1

Blood

2/8

0

0

5

5-1

Blood

2/3

0

0

6

6-1

Blood

8/75

0

0

7

7-1

Blood

5/100

0

0

8

8-1

Blood

5/60

0

0

9

9-1

Blood

2/7

0

0

10

10-1

Blood

5/200

0

0

11

11-1

Blood

5/50

0

0

12

12-1

Blood

3/6

0

0

12

12-2

Blood

2/2

0

0

12

12-3

Blood

4/4

0

0

12

12-4

Blood

13/13

0

0

12

12-5

Blood

20/20

10

0

12

12-6

Blood

7/9

2

0

12

12-7

Blood

27/27

0

ND

12

12-8

Blood

50/50

0

ND

12

12-9

Blood

0/0

-

-

12

12-10

Blood

2/2

0

0

13

13-1 (BL)

Blood

0/0

-

-

14

14-1 (BL)

Blood

0/6

-

-

15

15-1 (BL)

Blood

0/6

-

-

16

16-1 (BL)

Blood

0/0

-

-

17

17-1 (BL)

Blood

0/0

-

-

TOTALS

17 patients

30 samples

-

185/769

12

0

  1. CTCs circulating tumor cells, ND not determined.
  2. *CTCs not analyzed for mutations were used for transcriptional analysis [21], immunostaining, or other molecular assays.