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Table 1 Single cell mutation analysis of CTCs

From: Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Patient ID Sample ID Sample type Number CTCs analyzed/total CTCs collected* Number CTCs with PIK3CAexon 9 mutation Number CTCs with PIK3CAexon 20 mutation
1 1-1 Blood 3/13 0 0
1 1-2 Blood 3/9 0 0
1 1-3 Blood 4/9 0 0
2 2-1 Blood 3/20 0 0
2 2-2 Blood 2/6 0 0
2 2-3 Blood 5/50 0 0
3 3-1 Blood 3/14 0 0
4 4-1 Blood 2/8 0 0
5 5-1 Blood 2/3 0 0
6 6-1 Blood 8/75 0 0
7 7-1 Blood 5/100 0 0
8 8-1 Blood 5/60 0 0
9 9-1 Blood 2/7 0 0
10 10-1 Blood 5/200 0 0
11 11-1 Blood 5/50 0 0
12 12-1 Blood 3/6 0 0
12 12-2 Blood 2/2 0 0
12 12-3 Blood 4/4 0 0
12 12-4 Blood 13/13 0 0
12 12-5 Blood 20/20 10 0
12 12-6 Blood 7/9 2 0
12 12-7 Blood 27/27 0 ND
12 12-8 Blood 50/50 0 ND
12 12-9 Blood 0/0 - -
12 12-10 Blood 2/2 0 0
13 13-1 (BL) Blood 0/0 - -
14 14-1 (BL) Blood 0/6 - -
15 15-1 (BL) Blood 0/6 - -
16 16-1 (BL) Blood 0/0 - -
17 17-1 (BL) Blood 0/0 - -
TOTALS
17 patients 30 samples - 185/769 12 0
  1. CTCs circulating tumor cells, ND not determined.
  2. *CTCs not analyzed for mutations were used for transcriptional analysis [21], immunostaining, or other molecular assays.