|
A) miR-155
|
|---|
|
Parameter
|
Estimate
|
Standard error
|
p
-value
|
|
β
I
|
0.61774
|
0.06440
|
< 2e-16
|
|
β
II
|
−0.24024
|
0.05617
|
1.89e-05
|
|
β
III
|
−0.34474
|
0.05684
|
1.32e-09
|
|
β
C
|
−0.51148
|
0.11103
|
4.10e-06
|
|
β
L
|
−0.18353
|
0.08245
|
0.026
|
|
B) miR-19a
|
|
Parameter
|
Estimate
|
Standard error
|
p
-value
|
|
β
I
|
0.60941
|
0.04843
|
< 2e-16
|
|
β
II
|
0.03224
|
0.03187
|
0.31183
|
|
β
III
|
0.09981
|
0.03804
|
0.00869
|
|
β
C
|
0.34506
|
0.11439
|
0.00256
|
|
β
L
|
0.15711
|
0.07041
|
0.02567
|
|
C) miR-181b
|
|
Parameter
|
Estimate
|
Standard error
|
p
-value
|
|
β
I
|
0.70370
|
0.05176
|
< 2e-16
|
|
β
II
|
0.17814
|
0.03917
|
5.41e-06
|
|
β
III
|
0.17263
|
0.03884
|
8.80e-06
|
|
β
C
|
0.27792
|
0.10095
|
0.0059
|
|
β
L
|
0.16588
|
0.07403
|
0.0250
|
|
D) miR-24
|
|
Parameter
|
Estimate
|
Standard error
|
p
-value
|
|
β
I
|
0.50276
|
0.06718
|
7.19e-14
|
|
β
II
|
−0.14807
|
0.05429
|
0.00638
|
|
β
III
|
−0.12527
|
0.05527
|
0.02343
|
|
β
C
|
−0.34034
|
0.11512
|
0.00311
|
|
β
L
|
−0.22631
|
0.08774
|
0.00990
|
- Presented are parameters to calculate conditional expectation of the miR’s serum level for each BC patient/control at particular time point and their estimate values, their standard errors, and corresponding p-values for levels of miR-155 (A), miR-19a (B), miR-181b (C), and miR-24 (D), all relative to let-7a, in EBC sera. Parameters of oncomiR level: β
I
: time point I, β
II
: the difference between time points I and II, β
III
: the difference between time points I and III, β
C
: the difference between time point I and healthy control, and β
L
: the difference between high risk and low risk EBC patients.
