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Figure 4 | BMC Cancer

Figure 4

From: RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53 abnormalmyeloma cells independently of the p53 pathway

Figure 4

The RITA sensitivity of primary cells was not significantly related to TP53 status. A. The percentage of cell death of primary cells that were treated with RITA (upper panel) or nutlin3a (lower panel) was analyzed as a function of del(17p). del(17p)+: >19% of deleted cells; del(17p)-: ≤19% of deleted cells. B. The percentage of cell death of primary cells treated with RITA (upper panel) or nutlin3a (lower panel) was plotted against the percentage of del(17p) + cells within the samples. C. The fold increase in DR5 expression induced by RITA (upper panel) or nutlin3a (lower panel) was plotted against the percentage of del(17p) + cells within the samples. D. The fold increase in DR5 expression that was induced by RITA (upper panel) or nutlin3a (lower panel) was plotted against the percentage of cell death. E. The percentage of cell death of primary cells treated with RITA (left) or nutlin3a (right) was analyzed as a function of 14q32 translocation. Circle and triangle symbols represent samples without and with del(17p), respectively.

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BMC Cancer

ISSN: 1471-2407

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