Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity

Table 2 Heme oxygenamse-1 (HO-1) expression in CRC and its correlation with clinicopathological characteristics

Characteristics	No. of patients	HO-1 expression - (%) + (%)	Pvalue
Tissue character			0.0009^***
CRC	118	46 (39.0) 72 (61.0)
Non-tumoral adjacent parenchyma	37	26 (70.3) 11 (29.7)
Sex			0.586
Male	63	26 (41.3) 37 (58.7)
Female	55	20 (36.4) 35 (63.6)
Depth of wall invasion			0.441
T1/T2	24	11 (45.8) 13 (54.2)
T3/T4	94	35 (37.2) 59 (62.8)
Differentiation			0.011^*
Well differentiated	81	15 (18.5) 66 (81.5)
Poorly/moderately differentiated	37	15 (40.5) 22 (59.5)
Lymph node metastasis			0.079
Negative	75	26 (34.7) 49 (65.3)
Positive	43	22 (51.2) 21 (48.8)
Liver metastasis			0.56
Negative	114	45 (39.5) 69 (60.5)
Positive	4	1 (25) 3 (75)
TNM stages			0.281
I	18	6 (33.3) 12 (66.7)
II	54	24 (44.4) 30 (55.6)
III	40	21 (52.5) 19 (47.5)
IV	6	1 (16.7) 5 (83.3)

ISSN: 1471-2407