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Table 2 Heme oxygenamse-1 (HO-1) expression in CRC and its correlation with clinicopathological characteristics

From: Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity

Characteristics No. of patients HO-1 expression - (%) + (%) Pvalue
Tissue character    0.0009***
 CRC 118 46 (39.0) 72 (61.0)  
 Non-tumoral adjacent parenchyma 37 26 (70.3) 11 (29.7)  
Sex    0.586
 Male 63 26 (41.3) 37 (58.7)  
 Female 55 20 (36.4) 35 (63.6)  
Depth of wall invasion    0.441
 T1/T2 24 11 (45.8) 13 (54.2)  
 T3/T4 94 35 (37.2) 59 (62.8)  
Differentiation    0.011*
 Well differentiated 81 15 (18.5) 66 (81.5)  
 Poorly/moderately differentiated 37 15 (40.5) 22 (59.5)  
Lymph node metastasis    0.079
 Negative 75 26 (34.7) 49 (65.3)  
 Positive 43 22 (51.2) 21 (48.8)  
Liver metastasis    0.56
 Negative 114 45 (39.5) 69 (60.5)  
 Positive 4 1 (25) 3 (75)  
TNM stages    0.281
 I 18 6 (33.3) 12 (66.7)  
 II 54 24 (44.4) 30 (55.6)  
 III 40 21 (52.5) 19 (47.5)  
 IV 6 1 (16.7) 5 (83.3)  
  1. *P < 0.01; ***P < 0.001, Fisher's exact test.