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Table 1 Combination Index (CI) values at ED 50 and ED 75 in various cancer cell lines

From: Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim

Cell line Origin Drug ratio CI at ED50 CI at ED75
   DOX : Gami   
HeLa cervix 1 : 5 0.33 ± 0.03 0.41 ± 0.03
22Rv1 prostate 1 : 10 0.81 ± 0.18 0.53 ± 0.09
A172 brain 1 : 10 0.45 ± 0.28 0.76 ± 0.27
ACHN kidney 1 : 2 0.34 ± 0.11 0.20 ± 0.07
SK-Hep1 liver 1 : 5 0.31 ± 0.05 0.29 ± 0.03
NCI-H460 lung 1 : 5 0.32 ± 0.19 0.45 ± 0.29
SK-OV3 ovary 1 : 1 0.58 ± 0.13 0.95 ± 0.28
MDA-MB-231 breast 5 : 1 0.73 ± 0.27 0.46 ± 0.24
  1. NOTE: Cancer cells were treated with various concentrations of drugs at a fixed ratio as indicated. CI values at 50% (ED50) and 75% effective doses (ED75) were calculated from isobologram analysis. Data are the mean ± 1.96 s.d. (95% confidence interval) of two independent experiments performed in triplicate.