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Table 1 Correlation of 14-3-3σ and HSP70 with clinicopathological characteristics in primary HCC patients

From: 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma

Parameters 14-3-3σ expression (Q-score ≥ 2) % (n) p-value Hsp70 expression (Q-score ≥ 2) % (n) p-value
Overall (n = 109) 77.1% (84)   60.6% (66)  
Age   0.080   NS
  < 60 years (n = 56) 83.9% (47) 66.1% (37)
  ≥ 60 years (n = 53) 69.8% (37) 54.7% (29)
Gender   NS   0.097
  Male (n = 82) 79.3% (65) 56.1% (46)
  Female (n = 27) 70.4% (19) 74.1% (20)
Histology grade   NS   0.060
  1 (n = 7) 71.4% (5) 28.6% (2)
  2 (n = 77) 74.0% (57) 58.4% (45)
  3 (n = 25) 88.0% (22) 76.0% (19)
Types of surgery   NS   NS
  Wedge resection (n = 39) 69.2% (27) 56.4% (22)
  Segmentectomy (n = 54) 79.6% (43) 64.8% (35)
  Lobectomy (n = 16) 87.5% (14) 56.3% (9)
Surgical margin   0.008*   NS
  Free (n = 83) 71.1% (59) 61.4% (51)
  Involved (n = 26) 96.2% (25) 57.7% (15)
BCLC staging   NS   0.079
  Not available (n = 5)   
  Early (stage A1 to A4) (n = 56) 69.6% (39) 51.8% (29)
  Intermediate (stage B) (n = 46) 82.6% (38) 67.4% (31)
  Advanced (stage C) (n = 2) 100.0% (2) 100.0% (2)
Tumor size   0.062   0.062
  ≥ 5.0 cm (n = 34) 88.2% (30) 73.5% (25)
  < 5.0 cm (n = 75) 72.0% (54) 54.7% (41)
Tumor multiplicity   NS   NS
  Single (n = 84) 78.6% (66) 63.1% (53)
  Multiple (n = 25) 72.0% (18) 52.0% (13)
Capsular formation   0.028*   NS
  Not available (n = 8)   
  Yes (n = 59) 69.5% (41) 57.6% (34)
  No (n = 42) 88.1% (37) 66.7% (28)
Micro-vascular thrombi   0.001*   0.019*
  Yes (n = 48) 91.7% (44) 72.9% (35)
  No (n = 61) 65.6% (40) 50.8% (31)
Liver cirrhosis   NS   NS
  Not available (n = 3)   
  Yes (n = 55) 76.4% (42) 58.2% (32)
  No (n = 51) 78.4% (40) 64.7% (33)
Viral hepatitis   NS   NS
  Not available (n = 7)   
  Hepatitis B (n = 54) 79.6% (43) 61.1% (33)
  Hepatitis C (n = 30) 70.0% (21) 56.7% (17)
  Both (n = 15) 80.0% (12) 60.0% (9)
  None (n = 3) 66.7% (2) 66.7% (2)
Alpha-fetoprotein level   NS   0.009*
  Not available (n = 12)   
   80 ng/ml (n = 35) 80.0% (28) 77.1% (27)
  < 80 ng/ml (n = 62) 74.2% (46) 50.0% (31)
Subsequent extrahepatic metastasis   NS   NS
  Yes (n = 29) 82.8%(24) 65.5% (19)
  No (n = 80) 75.0%(60)   58.8% (47)  
  1. BCLC, Barcelona-Clinic Liver Cancer; NS, not significant; Q-score, Quick-score.
  2. *p < 0.05; 0.05 < p < 0.10.