Table 1 Correlation of 14-3-3σ and HSP70 with clinicopathological characteristics in primary HCC patients
From: 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma
Parameters | 14-3-3σ expression (Q-score ≥ 2) % (n) | p-value | Hsp70 expression (Q-score ≥ 2) % (n) | p-value |
|---|---|---|---|---|
Overall (n = 109) | 77.1% (84) | 60.6% (66) | ||
Age | 0.080† | NS | ||
< 60 years (n = 56) | 83.9% (47) | 66.1% (37) | ||
≥ 60 years (n = 53) | 69.8% (37) | 54.7% (29) | ||
Gender | NS | 0.097† | ||
Male (n = 82) | 79.3% (65) | 56.1% (46) | ||
Female (n = 27) | 70.4% (19) | 74.1% (20) | ||
Histology grade | NS | 0.060† | ||
1 (n = 7) | 71.4% (5) | 28.6% (2) | ||
2 (n = 77) | 74.0% (57) | 58.4% (45) | ||
3 (n = 25) | 88.0% (22) | 76.0% (19) | ||
Types of surgery | NS | NS | ||
Wedge resection (n = 39) | 69.2% (27) | 56.4% (22) | ||
Segmentectomy (n = 54) | 79.6% (43) | 64.8% (35) | ||
Lobectomy (n = 16) | 87.5% (14) | 56.3% (9) | ||
Surgical margin | 0.008* | NS | ||
Free (n = 83) | 71.1% (59) | 61.4% (51) | ||
Involved (n = 26) | 96.2% (25) | 57.7% (15) | ||
BCLC staging | NS | 0.079† | ||
Not available (n = 5) | ||||
Early (stage A1 to A4) (n = 56) | 69.6% (39) | 51.8% (29) | ||
Intermediate (stage B) (n = 46) | 82.6% (38) | 67.4% (31) | ||
Advanced (stage C) (n = 2) | 100.0% (2) | 100.0% (2) | ||
Tumor size | 0.062† | 0.062† | ||
≥ 5.0 cm (n = 34) | 88.2% (30) | 73.5% (25) | ||
< 5.0 cm (n = 75) | 72.0% (54) | 54.7% (41) | ||
Tumor multiplicity | NS | NS | ||
Single (n = 84) | 78.6% (66) | 63.1% (53) | ||
Multiple (n = 25) | 72.0% (18) | 52.0% (13) | ||
Capsular formation | 0.028* | NS | ||
Not available (n = 8) | ||||
Yes (n = 59) | 69.5% (41) | 57.6% (34) | ||
No (n = 42) | 88.1% (37) | 66.7% (28) | ||
Micro-vascular thrombi | 0.001* | 0.019* | ||
Yes (n = 48) | 91.7% (44) | 72.9% (35) | ||
No (n = 61) | 65.6% (40) | 50.8% (31) | ||
Liver cirrhosis | NS | NS | ||
Not available (n = 3) | ||||
Yes (n = 55) | 76.4% (42) | 58.2% (32) | ||
No (n = 51) | 78.4% (40) | 64.7% (33) | ||
Viral hepatitis | NS | NS | ||
Not available (n = 7) | ||||
Hepatitis B (n = 54) | 79.6% (43) | 61.1% (33) | ||
Hepatitis C (n = 30) | 70.0% (21) | 56.7% (17) | ||
Both (n = 15) | 80.0% (12) | 60.0% (9) | ||
None (n = 3) | 66.7% (2) | 66.7% (2) | ||
Alpha-fetoprotein level | NS | 0.009* | ||
Not available (n = 12) | ||||
≧ 80 ng/ml (n = 35) | 80.0% (28) | 77.1% (27) | ||
< 80 ng/ml (n = 62) | 74.2% (46) | 50.0% (31) | ||
Subsequent extrahepatic metastasis | NS | NS | ||
Yes (n = 29) | 82.8%(24) | 65.5% (19) | ||
No (n = 80) | 75.0%(60) | 58.8% (47) |