Differential expression patterns and clinical significance of estrogen receptor-α and β in papillary thyroid carcinoma

Table 4 Associations between subcellular localization of ERα/ERβ1 and biological markers in female PTC patients

ERα	Ki-67		Mutant P53		VEGF
Reproductive age^a
Subcellular localization	Positive percentage	Total score^c	Positive percentage	Total score	Positive percentage	Total score
Nu (n = 28)	27/28 (96.4%)	4.04 ± 1.07	21/28 (75.0%)	4.75 ± 2.98	26/28 (92.9%)	5.93 ± 2.14
Nu + Cyto/Cyto (n = 8)	8/8 (100%)	4.13 ± 0.64	5/8 (62.5%)	3.88 ± 3.36	8/8 (100%)	5.88 ± 1.81
P-value	0.588	0.983	0.486	0.562	0.437	0.683
Advanced reproductive age ^b
Nu (n = 7)	6/7 (85.7%)	3.43 ± 1.51	4/7 (57.1%)	3.71 ± 3.50	3/7 (42.9%)	2.29 ± 3.09
Nu + Cyto/Cyto (n = 11)	8/11 (72.7%)	3.55 ± 2.30	8/11 (72.7%)	5.18 ± 3.37	8/11 (72.7%)	4.09 ± 3.05
P-value	0.518	0.121	0.494	0.182	0.205	0.205
ERβ1	Ki-67		Mutant P53		VEGF
Reproductive age
Subcellular localization	Positive percentage	Total score	Positive percentage	Total score	Positive percentage	Total score
Nu (n = 7)	6/7 (85.7%)	3.29 ± 1.60	6/7 (85.7%)	6.00 ± 2.77	4/7 (57.1%)	3.29 ± 3.15
Nu + Cyto/Cyto (n = 41)	40/41 (97.6%)	4.00 ± 1.00	28/41 (68.3%)	4.27 ± 3.11	41/41 (100%)	6.32 ± 1.47
P-value	0.147	0.227	0.349	0.118	0.000	0.015
Advanced reproductive age
Nu (n = 3)	2/3 (66.7%)	2.67 ± 2.31	2/3 (66.7%)	4.67 ± 4.04	1/3 (33.3%)	2.33 ± 4.04
Nu + Cyto/Cyto (n = 36)	31/36 (86.1%)	3.81 ± 1.65	22/36 (61.1%)	4.14 ± 3.41	24/36 (66.7%)	3.61 ± 2.98
P-value	0.370	0.199	0.849	0.699	0.248	0.497

^aThe female patients of reproductive age were 18–45 years old. ^bThose of advanced reproductive age were all above 45 years old. ^cTotal score was calculated from the sum of proportion staining score and intensity score to reflect the expression level, which is given as mean ± S.D. PTC, papillary thyroid cancer; Nu, exclusively nuclear staining; Nu + Cyto, combined nuclear and cytoplasmic staining; Cyto, exclusively cytoplasmic staining.

ISSN: 1471-2407