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Table 7 Risk of colorectal cancer, overall and according to clinicopathological factors, in relation to oral contraceptive (OC) use in colon and rectum

From: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

  Colon Rectum
Tumour subgroups OC use n HR crude p HR adjusted p n HR crude p HR adjusted p
CRC No 116 1.00   1.00   69 1.00   1.00  
OC 59 1.00(0.73-1.37) 0.998 1.41(0.96-2.08) 0.080 37 1.02(0.68-1.53) 0.934 0.97(0.59-1.60) 0.900
T stage 1&2 No 22 1.00   1.00   21 1.00   1.00  
OC 8 0.72(0.32-1.62) 0.422 1.43(0.56-3.66) 0.462 8 0.76(0.33-1.76) 0.521 0.67(0.23-1.89) 0.445
T stage 3 &4 No 89 1.00   1.00   34 1.00   1.00  
OC 49 1.08(0.76-1.54) 0.655 1.43(0.93-2.22) 0.107 24 1.22(0.72-2.07) 0.460 1.27(0.64-2.53) 0.488
N0 No 63 1.00   1.00   37 1.00   1.00  
OC 26 0.77(0.49-1.22) 0.271 1.17(0.67-2.03) 0.582 18 0.93(0.52-1.66) 0.811 0.90(0.43-1.88) 0.780
N1 & N2 No 43 1.00   1.00   17 1.00   1.00  
OC 30 1.38(0.86-2.20) 0.181 1.81(1.00-3.28) 0.051 12 1.20(0.57-2.52) 0.630 1.00(0.39-2.56) 1.000
M0 No 88 1.00   1.00   57 1.00   1.00  
OC 47 1.05(0.73-1.49) 0.804 1.55(1.00-2.40) 0.050 31 1.00(0.64-1.56) 0.999 0.83(0.47-1.45) 0.507
M1 No 26 1.00   1.00   9 1.00   1.00  
OC 12 0.90(0.45-1.80) 0.771 0.96(0.41-2.30) 0.955 5 1.09(0.35-3.36) 0.880 1.75(0.44-6.86) 0.425
beta-catenin+ No 56 1.00   1.00   43 1.00   1.00  
OC 24 0.84(0.52-1.37) 0.489 1.36(0.75-2.47) 0.308 24 1.02(0.62-1.70) 0.931 1.00(0.53-1.88) 1.000
beta-catenin− No 45 1.00   1.00   14 1.00   1.00  
OC 29 1.27(0.79-2.03) 0.322 1.70(0.97-3.00) 0.065 10 1.41(0.61-3.24) 0.421 1.00(0.35-2.87) 1.000
cyclin D1+ No 88 1.00   1.00   44 1.00   1.00  
OC 46 1.04(0.72-1.47) 0.843 1.62(1.04-2.51) 0.032 24 1.06(0.64-1.76) 0.826 1.04(0.56-1.95) 0.893
cyclin D1− No 15 1.00   1.00   14 1.00   1.00  
OC 8 1.00(0.42-2.36) 0.999 0.90(0.31-2.60) 0.844 7 0.82(0.33-2.03) 0.666 0.77(0.24-2.48) 0.660
p53+ No 45 1.00   1.00   32 1.00   1.00  
OC 20 0.90(0.52-1.53) 0.685 1.28(0.67-2.45) 0.451 22 1.37(0.78-2.39) 0.274 1.00(0.49-2.02) 1.000
p53− No 59 1.00   1.00   26 1.00   1.00  
OC 34 1.11(0.73-1.70) 0.625 1.54(0.90-2.63) 0.115 9 0.59(0.28-1.27) 0.177 0.52(0.21-1.30) 0.161
MSI No 25 1.00   1.00   2 1.00   1.00  
OC 14 1.08(0.56-2.09) 0.809 1.85(0.82-1.18) 0.139 0 -   -  
MSS No 76 1.00   1.00   54 1.00   1.00 1.000
  OC 39 1.02(0.69-1.50) 0.938 1.43(0.89-2.32) 0.143 32 1.10(0.70-1.72) 0.678 1.00(0.58-1.74)  
  1. Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.