Table 7 Risk of colorectal cancer, overall and according to clinicopathological factors, in relation to oral contraceptive (OC) use in colon and rectum
Colon | Rectum | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Tumour subgroups | OC use | n | HR crude | p | HR adjusted | p | n | HR crude | p | HR adjusted | p |
CRC | No | 116 | 1.00 | 1.00 | 69 | 1.00 | 1.00 | ||||
OC | 59 | 1.00(0.73-1.37) | 0.998 | 1.41(0.96-2.08) | 0.080 | 37 | 1.02(0.68-1.53) | 0.934 | 0.97(0.59-1.60) | 0.900 | |
T stage 1&2 | No | 22 | 1.00 | 1.00 | 21 | 1.00 | 1.00 | ||||
OC | 8 | 0.72(0.32-1.62) | 0.422 | 1.43(0.56-3.66) | 0.462 | 8 | 0.76(0.33-1.76) | 0.521 | 0.67(0.23-1.89) | 0.445 | |
T stage 3 &4 | No | 89 | 1.00 | 1.00 | 34 | 1.00 | 1.00 | ||||
OC | 49 | 1.08(0.76-1.54) | 0.655 | 1.43(0.93-2.22) | 0.107 | 24 | 1.22(0.72-2.07) | 0.460 | 1.27(0.64-2.53) | 0.488 | |
N0 | No | 63 | 1.00 | 1.00 | 37 | 1.00 | 1.00 | ||||
OC | 26 | 0.77(0.49-1.22) | 0.271 | 1.17(0.67-2.03) | 0.582 | 18 | 0.93(0.52-1.66) | 0.811 | 0.90(0.43-1.88) | 0.780 | |
N1 & N2 | No | 43 | 1.00 | 1.00 | 17 | 1.00 | 1.00 | ||||
OC | 30 | 1.38(0.86-2.20) | 0.181 | 1.81(1.00-3.28) | 0.051 | 12 | 1.20(0.57-2.52) | 0.630 | 1.00(0.39-2.56) | 1.000 | |
M0 | No | 88 | 1.00 | 1.00 | 57 | 1.00 | 1.00 | ||||
OC | 47 | 1.05(0.73-1.49) | 0.804 | 1.55(1.00-2.40) | 0.050 | 31 | 1.00(0.64-1.56) | 0.999 | 0.83(0.47-1.45) | 0.507 | |
M1 | No | 26 | 1.00 | 1.00 | 9 | 1.00 | 1.00 | ||||
OC | 12 | 0.90(0.45-1.80) | 0.771 | 0.96(0.41-2.30) | 0.955 | 5 | 1.09(0.35-3.36) | 0.880 | 1.75(0.44-6.86) | 0.425 | |
beta-catenin+ | No | 56 | 1.00 | 1.00 | 43 | 1.00 | 1.00 | ||||
OC | 24 | 0.84(0.52-1.37) | 0.489 | 1.36(0.75-2.47) | 0.308 | 24 | 1.02(0.62-1.70) | 0.931 | 1.00(0.53-1.88) | 1.000 | |
beta-catenin− | No | 45 | 1.00 | 1.00 | 14 | 1.00 | 1.00 | ||||
OC | 29 | 1.27(0.79-2.03) | 0.322 | 1.70(0.97-3.00) | 0.065 | 10 | 1.41(0.61-3.24) | 0.421 | 1.00(0.35-2.87) | 1.000 | |
cyclin D1+ | No | 88 | 1.00 | 1.00 | 44 | 1.00 | 1.00 | ||||
OC | 46 | 1.04(0.72-1.47) | 0.843 | 1.62(1.04-2.51) | 0.032 | 24 | 1.06(0.64-1.76) | 0.826 | 1.04(0.56-1.95) | 0.893 | |
cyclin D1− | No | 15 | 1.00 | 1.00 | 14 | 1.00 | 1.00 | ||||
OC | 8 | 1.00(0.42-2.36) | 0.999 | 0.90(0.31-2.60) | 0.844 | 7 | 0.82(0.33-2.03) | 0.666 | 0.77(0.24-2.48) | 0.660 | |
p53+ | No | 45 | 1.00 | 1.00 | 32 | 1.00 | 1.00 | ||||
OC | 20 | 0.90(0.52-1.53) | 0.685 | 1.28(0.67-2.45) | 0.451 | 22 | 1.37(0.78-2.39) | 0.274 | 1.00(0.49-2.02) | 1.000 | |
p53− | No | 59 | 1.00 | 1.00 | 26 | 1.00 | 1.00 | ||||
OC | 34 | 1.11(0.73-1.70) | 0.625 | 1.54(0.90-2.63) | 0.115 | 9 | 0.59(0.28-1.27) | 0.177 | 0.52(0.21-1.30) | 0.161 | |
MSI | No | 25 | 1.00 | 1.00 | 2 | 1.00 | 1.00 | ||||
OC | 14 | 1.08(0.56-2.09) | 0.809 | 1.85(0.82-1.18) | 0.139 | 0 | - | - | |||
MSS | No | 76 | 1.00 | 1.00 | 54 | 1.00 | 1.00 | 1.000 | |||
OC | 39 | 1.02(0.69-1.50) | 0.938 | 1.43(0.89-2.32) | 0.143 | 32 | 1.10(0.70-1.72) | 0.678 | 1.00(0.58-1.74) | ||