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Table 4 Risk of CRC and clinicopathological subgrops in relation to HRT and ERT use in colon and rectum

From: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

  Colon Rectum  
Tumour subgroups HRT use n HR crude p HR adjusted p n HR crude p HR adjusted p
CRC No 150 1.00   1.00   81 1.00   1.00  
ERT 15 1.21(0.71-2.06) 0.488 1.17(0.67-2.02) 0.584 8 0.49(0.23-1.03) 0.061 0.38(0.17-0.86) 0.020
CHRT 28 1.04(0.68-1.57) 0.873 1.16(0.74-1.80) 0.521 13 0.44(0.23-0.86) 0.017 0.32(0.14-0.71) 0.005
T stage 1 & 2 No 27 1.00   1.00   24 1.00   1.00  
ERT 1 0.52(0.07-3.89) 0.525 0.34(0.04-2.70) 0.308 2 0.32(0.07-1.45) 0.138 0.11(0.02-0.67) 0.017
CHRT 1 0.21(0.03-1.54) 0.125 0.24(0.03-1.90) 0.178 2 0.09(0.01-0.76) 0.026 0.03(0.00-0.36) 0.031
T stage 3 & 4 No 117 1.00   1.00   42 1.00   1.00  
ERT 13 1.29(0.73-2.30) 0.381 1.30(0.72-2.35) 0.384 4 0.53(0.19-1.48) 0.223 0.51(0.17-1.55) 0.233
CHRT 24 1.17(0.75-1.83) 0.486 1.27(0.78-2.04) 0.335 8 0.72(0.33-1.58) 0.414 0.74(0.28-1.94) 0.533
N0 No 72 1.00   1.00   45 1.00   1.00  
ERT 11 1.72(0.91-3.26) 0.096 1.54(0.79-3.00) 0.203 3 0.36(0.11-1.20) 0.097 0.31(0.08-1.13) 0.076
CHRT 16 1.20(0.70-2.08) 0.508 1.49(0.83-2.67) 0.183 6 0.29(0.10-0.85) 0.024 0.22(0.06-0.77) 0.222
N1 & N2 No 64 1.00   1.00   18 1.00   1.00  
ERT 4 0.76(0.28-2.10) 0.596 0.79(0.28-2.23) 0.659 3 1.03(0.30-3.56) 0.959 1.00(0.26-3.92) 1.000
CHRT 10 0.90(0.46-1.77) 0.762 0.79(0.37-1.65) 0.522 5 1.18(0.42-3.34) 0.757 1.00(0.27-3.73) 1.000
M0 No 114 1.00   1.00   64 1.00   1.00  
ERT 13 1.38(0.77-2.46) 0.277 1.25(0.69-2.26) 0.471 7 0.54(0.24-1.20) 0.130 0.43(0.18-1.03) 0.057
CHRT 22 1.10(0.69-1.74) 0.695 1.21(0.74-1.97) 0.446 12 0.54(0.29-1.09) 0.084 0.42(0.18-0.98) 0.044
M1 No 32 1.00   1.00   13 1.00   1.00  
ERT 3 1.04(0.32-3.40) 0.953 1.24(0.37-4.16) 0.732 1 0.31(0.04-2.48) 0.269 0.32(0.03-3.24) 0.335
CHRT 6 1.06(0.44-2.56) 0.900 1.13(0.42-3.00) 0.809 1 0.14(0.02-1.22) 0.075 0.06(0.00-1.18) 0.064
  1. Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.