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Table 4 Risk of CRC and clinicopathological subgrops in relation to HRT and ERT use in colon and rectum

From: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

 

Colon

Rectum

 

Tumour subgroups

HRT use

n

HR crude

p

HR adjusted

p

n

HR crude

p

HR adjusted

p

CRC

No

150

1.00

 

1.00

 

81

1.00

 

1.00

 

ERT

15

1.21(0.71-2.06)

0.488

1.17(0.67-2.02)

0.584

8

0.49(0.23-1.03)

0.061

0.38(0.17-0.86)

0.020

CHRT

28

1.04(0.68-1.57)

0.873

1.16(0.74-1.80)

0.521

13

0.44(0.23-0.86)

0.017

0.32(0.14-0.71)

0.005

T stage 1 & 2

No

27

1.00

 

1.00

 

24

1.00

 

1.00

 

ERT

1

0.52(0.07-3.89)

0.525

0.34(0.04-2.70)

0.308

2

0.32(0.07-1.45)

0.138

0.11(0.02-0.67)

0.017

CHRT

1

0.21(0.03-1.54)

0.125

0.24(0.03-1.90)

0.178

2

0.09(0.01-0.76)

0.026

0.03(0.00-0.36)

0.031

T stage 3 & 4

No

117

1.00

 

1.00

 

42

1.00

 

1.00

 

ERT

13

1.29(0.73-2.30)

0.381

1.30(0.72-2.35)

0.384

4

0.53(0.19-1.48)

0.223

0.51(0.17-1.55)

0.233

CHRT

24

1.17(0.75-1.83)

0.486

1.27(0.78-2.04)

0.335

8

0.72(0.33-1.58)

0.414

0.74(0.28-1.94)

0.533

N0

No

72

1.00

 

1.00

 

45

1.00

 

1.00

 

ERT

11

1.72(0.91-3.26)

0.096

1.54(0.79-3.00)

0.203

3

0.36(0.11-1.20)

0.097

0.31(0.08-1.13)

0.076

CHRT

16

1.20(0.70-2.08)

0.508

1.49(0.83-2.67)

0.183

6

0.29(0.10-0.85)

0.024

0.22(0.06-0.77)

0.222

N1 & N2

No

64

1.00

 

1.00

 

18

1.00

 

1.00

 

ERT

4

0.76(0.28-2.10)

0.596

0.79(0.28-2.23)

0.659

3

1.03(0.30-3.56)

0.959

1.00(0.26-3.92)

1.000

CHRT

10

0.90(0.46-1.77)

0.762

0.79(0.37-1.65)

0.522

5

1.18(0.42-3.34)

0.757

1.00(0.27-3.73)

1.000

M0

No

114

1.00

 

1.00

 

64

1.00

 

1.00

 

ERT

13

1.38(0.77-2.46)

0.277

1.25(0.69-2.26)

0.471

7

0.54(0.24-1.20)

0.130

0.43(0.18-1.03)

0.057

CHRT

22

1.10(0.69-1.74)

0.695

1.21(0.74-1.97)

0.446

12

0.54(0.29-1.09)

0.084

0.42(0.18-0.98)

0.044

M1

No

32

1.00

 

1.00

 

13

1.00

 

1.00

 

ERT

3

1.04(0.32-3.40)

0.953

1.24(0.37-4.16)

0.732

1

0.31(0.04-2.48)

0.269

0.32(0.03-3.24)

0.335

CHRT

6

1.06(0.44-2.56)

0.900

1.13(0.42-3.00)

0.809

1

0.14(0.02-1.22)

0.075

0.06(0.00-1.18)

0.064

  1. Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.